Biogen Ma Inc.

Neurimmune Ag

Isin Dalkilic-Liddle

R Blake Pepinsky

Jan Grimm

Fabio Montrasio

Mia Marie Rushe

Joseph Arndt

Thomas O Cameron

Karl J M Hanf

Benjamin A Smith

Fang Qian

Provided are novel dipeptide repeat (DPR) specific antibodies (e.g., human-derived antibodies) as well as synthetic variants and biotechnological derivatives thereof, capable of binding C9orf72 poly-glycine-alanine DPRs, as well as methods and uses related thereto. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.

Human-derived anti-(poly-GA) dipeptide repeat (DPR) antibody

The present disclosure provides anti-transferrin receptor antibodies, compositions comprising the same and methods of their use. This disclosure also provides polynucleotides and vectors encoding the anti-transferrin receptor antibodies and cells comprising the same, methods of making the antibodies, and molecules comprising the antibodies.

Anti-transferrin receptor antibodies and uses thereof

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Watertown, MA, United States of America

Isin Dalkilic-Liddle