Columbia University

Isidore S Edelman

James J Russo

Yuan Chang

Patrick S Moore

Roy A Bohenzky

Bernard F Erlanger

William L Cleveland

Eftihia Tzilianos

This invention provides an isolated nucleic acid molecule which encodes Kaposi's Sarcoma-Associated Herpesvirus (KSHV) polypeptides. This invention provides an isolated polypeptide molecule of KSHV. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.

Unique associated Kaposi's sarcoma virus sequences and uses thereof

Unique associated Kaposi's Sarcoma virus sequences and uses thereof

This invention provides an isolated nucleic acid molecule which encodes Kaposi's Sarcoma-Associated Herpesvirus (KSHV) immediate early protein (IEP). This invention provides an isolated polypeptide molecule which encodes KSHV immediate early protein. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.

Immediate early protein from Kaposi's sarcoma-associated herpesvirus,

This invention provides an isolated DNA molecule which encodes glycoprotein B (gB). Antisense and triplex oligonucleotide molecules are also provided.

Kaposi's sarcoma-associated herpesvirus (KSHV) glycoprotein B (GB) and

This invention provides an isolated DNA molecule which encodes interleukin 6 (IL-6) of Kaposi's sarcoma-associated herpesvirus. Antisense oligonucleotide molecules are also provided.

Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin 6 (IL-6) and

This invention provides an isolated nucleic acid molecule which encodes KSHV virion protein 26. This invention provides an isolated polypeptide molecule which encodes KSHV virion protein 26. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine and method of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.

Virion protein 26 from Kaposi's sarcoma-associated herpesvirus, DNA

This invention provides an isolated nucleic acid molecule which encodes KSHV glycoprotein L (gL). This invention provides an isolated nucleic acid molecule which encodes KSHV glycoprotein M (gM). This invention provides isolated gL and gM polypeptides. This invention provides antibodies specific to the polypeptides. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.

Glycoprotein L and clycoprotein M from kaposi's sarcoma associated

This invention provides an antibody specific to the peptide of KSHVIL-6.

This invention provides an isolated DNA molecule which encodes viral macrophage inflammatory protein-1.alpha. II (vMIP-1.alpha. II). Antisense and oligonucleotide molecules are also provided.

Kaposi's sarcoma-associated herpesvirus (KSHV) viral macrophage

Polypeptides from Kaposi's sarcoma-associated herpesvirus, DNA encoding

This invention provide an isolated DNA molecule which encodes interferon consensus sequence binding protein (ICSBP).

Kaposi's sarcoma-associated herpes virus (KSHV) interferon consensus

A competitive immunoassay for a steroid receptor has been developed in which monoclonal antibodies capable of binding to the steroid receptor are competitively bound by anti-steroid antibodies capable of binding to the steroid. The presence or amount of monoclonal antibody-anti-steroid antibody complex formed is related to the amount of steroid receptor present in the assayed material. A histochemical assay is also provided for detecting the amount of a steroid-receptor complex in a biological sample. This assay involves (1) adding an amount of steroid to the sample to form a steroid-receptor complex; (2) contacting the complex with a monoclonal antibody capable of binding to the complex; (3) removing any unbound monoclonal antibody; (4) adding a detectably labeled antibody capable of binding to the monoclonal antibody; (5) determining the amount of labeled antibody bound to the monoclonal antibody; and (6) determining the amount of steroid-receptor complex. The invention further provides a method of purifying receptors to a steroid hormone using monoclonal antibodies capable of binding to the receptor, and a method for producing a monoclonal anti-idiotypic antibody capable of binding to a steroid receptor.

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New York, NY, United States of America

Isidore S Edelman