Sphaera Pharma Pvt. Ltd.

Epirium Bio Inc.

Ishwar Rakesh Patil

Sundeep Dugar

Dinesh Mahajan

Kumar Santosh Rai

Vinayak Tripathi

Sarbjit Singh

The present invention provides novel analogs of epicatechin and related polyphenols, their variously functionalized derivatives, process for preparation of the same, composition comprising these compounds and their method of use.

Analogues of epicatechin and related polyphenols

A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or &#x2212;) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (&#x2212;)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

Approach for synthesis of catechins

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Haryana, India

Ishwar Rakesh Patil