Massachusetts Institute of Technology

Ishan Barman

Ramachandra Rac Dasari

Jeon Woong Kang

Narahara Chari Dingari

Michael S Feld

Nam Pyo Suh

Sang-Gook Kim

Taesik Lee

Chae-Ryon Kong

Gyunyoung Heo

The present invention relates to the optical measurement of blood analytes, such as glycated hemoglobin (HbA1c) and serum albumin as a functional metric of mean blood glucose in the diagnosis of diabetic patients. Non-enhanced Raman spectroscopy is employed as the analytical method for quantitative detection of blood analytes. Using processing techniques, non-enzymatic glycosylation (glycation) of the analytes results in measurable and highly reproducible changes in the acquired spectral data, which enable the accurate measurements and classification of glycated and unglycated analytes.

Raman spectroscopy for detection of glycated analytes

The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.

Portable raman diagnostic system

A water desalination system and method in accordance with the principles of the present invention employs capacitive deionization to remove ions from source water to produce deionzed and waste water. The process employs charged electrodes to attract ions of opposite polarity from the source water. The process of discharging the electrodes employs solvent drag.

Method and apparatus for permeating flow desalination

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Ishan Barman