State of Israel, Represented by the Prime Minister's Office, Israel

Ishal Karton

Abraham Fisher

Aharon Levy

Yona Grunfeld

Eliahu Heidman

The (+)-cis-, (-)-cis-, (+)-trans- and (-)-trans- forms of 2-methylspiro(1,3-oxathiolan-5,3')quinuclidine are prepared by optical resolution of each of the (.+-.)-cis- and (.+-.)-trans-isomers. These compounds find application in treating diseases of the central nervous system in mammals, especially diseases due to a deficiency in the central cholinergic system. Biological tests indicate that the (-)-cis-form, as well as the (.+-.)-cis-isomer, shows particular promise for treating senile dementia of Alzheimer's type.

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Ness-Ziona, Israel

Ishal Karton