Codexis, Inc.

Ish Kumar Dhawan

Xiyun Zhang

Gregory Miller

Jie Yang

Andrew Shaw

Dipnath Baidyaroy

Kripa Rao

Onorato Campopiano

Brian R Scott

Christopher Hill

Erika Noel Segraves

Chengsong Liu

Oleh Tanchak

Amala Chokshi

Sachin Patil

Emily Mundorff

Richard John Fox

Matthew B Tobin

Birthe Borup

Sally Rhiannon Postlethwaite

Ranjini Chatterjee

Kenneth W Mitchell

Svetlana Balatskaya

Les Partridge

Sally Postlethwaite

The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.

Transaminase polypeptides

Polynucleotides encoding transaminase polypeptides

The present invention provides improved fungal strains. In some embodiments, the improved fungal strains find use in hydrolyzing cellulosic material to glucose.

Fungal strains

The present invention relates to variant endoglucanases having improved thermoactivity, improved thermostability, and improved viscosity reduction activity over wild-typeendoglucanase.

Endoglucanase variants

Engineered transaminase polypeptides

The invention provides variants of theendoglucanase (CelG) that have improved endoglucanase activity compared to the wild type enzyme. Also provided are related polynucleotides, compositions, vectors, host cells, and methods of use.

Variant endoglucanases and related polynucleotides

The invention provides variants of asp. CBH2 that have improved properties compared to the wild type enzyme and methods of using the variants in the hydrolysis of substrates comprising cellulose.

Variant CBH2 cellulases and related polynucleotides

Growing community of inventors

Foster City, CA, United States of America

Ish Kumar Dhawan