Eisai Company, Limited

Agency of Industrial Science and Technology

Nagoya University

Eisai Inc.

Isao Yamatsu

Shinya Abe

Takeshi Suzuki

Hiroyuki Yoshimura

Koukichi Harada

Yuichi Inai

Kazuo Okano

Mitsuaki Miyamoto

Shuhei Miyazawa

Tetsuya Kawahara

Kouichi Katayama

Kouji Nakamoto

Kouji Yamada

Akiharu Kajiwara

Shigeru Souda

Yoshimasa Machida

Shigeki Hibi

Naoyuki Shimomura

Manabu Murakami

Youji Yamagishi

Yoshikazu Suzuki

Takashi Yamanaka

Kenzo Muramoto

Shizumasa Kijima

Kenji Hayashi

Osamu Asano

Tohru Fujimori

Kozo Akasaka

Hajime Tsunoda

Hironori Ikuta

Richard S Clark

Toshiji Igarashi

Katsuya Tagami

Yasushi Okamoto

Satoshi Katayama

Hiroshi Obaishi

Kenichi Chiba

Takashi Mori

Yoshimori Sakuma

Kouichi Suzuki

Osamu Tagaya

Takashi Inoue

Kiyoshi Oketani

Kazuo Hirota

Hiroshi Shirota

Hideki Ono

Ryoichi Hashida

Tsutomu Yoshimura

Hiroyuki Shiojiri

Norio Minami

Mitsuo Nagai

Seiichi Araki

Masaichi Yamamoto

Yoshikage Nakajima

Haruyoshi Arai

Hiroshi Yamamoto

Seiichi Kobayashi

Hisashi Shibata

Kouichi Kikuchi

Yorihisa Hoshino

Tsutomu Kawata

Kimio Hamamura

Hideaki Watanabe

Junsaku Nagaoka

Masanori Mizuno

Masayuki Tanaka

Yoshio Tanabe

Toshihiko Kaneko

Seiichiro Nomoto

Makoto Okita

Ieharu Hishinuma

Junichi Nagakawa

Masanobu Shinoda

Hideaki Fujisaki

Naoki Kobayashi

Kouzi Yamada

Masaki Goto

Hideto Ohhara

Toru Horie

Hideki Sakurai

Shinichi Kitamura

Yoshimasa Takahara

Koichi Abe

Kenji Nakajima

Akio Sato

Kaname Miyamoto

Hiromitsu Yokohama

Yasunori Akita

Koichi Katayama

Toshiharu Ohgoh

Hiroshi Suzuki

Koichi Kikuchi

Nozomu Koyanagi

Takayuki Hida

Makoto Asada

Norimasa Miyamoto

Yoshinori Sakuma

Aichi Ogasawara

Tetsuya Tajima

Eiichi Morita

A &bgr;,&ggr;-dihydropolyprenyl alcohol derivative having the formula:

&bgr;,&ggr;-dihydropolyprenyl alcohol derivatives and pharmaceutical composition containing a polyprenyl compound

A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a prophylactic therapeutic agent for human and animal immuno-deficiency deseases and phylactic agent against human and animal infectious deseases. Another disclosed polyprenyl compound is also useful as the same agent.

Beta, gamma-dihydropolyprenyl alcohol derivatives and pharmaceutical

The present invention provides a therapeutic agent for fundamentally preventing, treating or ameliorating dermatosis, such as, non-infectious dermatosis, which include psoriasis and atopic dermatitis. The therapeutic agent comprises a glycerol derivative represented by the formula (I): ##STR1## wherein A is a group represented by the formula: ##STR2## or single bond; R.sup.1 is a group represented by the formula: ##STR3## wherein R.sup.2 is a methoxyphenyl group or methyl group, X is an atom or atomic group which may become an anion or a group represented by the formula: ##STR4## or a pharmacologically acceptable salt thereof as an active ingredient.

Therapeutic agent for dermatosis

To provide a treating or ameliorating agent for joint diseases accompanied with arthritis, preferably, a rheumatoid arthritis or ameliorating agent, which exerts excellent pharmaceutical effects. The active ingredient is a quinone derivative represented by the following general formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein n is 0 or an integer of 1 to 12 and R is a methyl or methoxy group.

Therapeutic agent for treating joint diseases associated with arthritis

Various .beta.,.gamma.-dihydropolyprenyl alcohol derivatives having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group are effective at pritigating stress in animals.

.beta., .gamma.-dihydropolyprenyl alcohol derivatives effective at

A benzothiazole derivative or a pharmacologically acceptable salt thereof of the following formula, as defined in the claims, which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective: ##STR1##

Benzothiazole compounds which are substituted by pyridymethyl

An aminobenzoic acid derivative represented by the following general formulas (I), (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group; R.sup.3 represents a halogen atom; X represents --O-- or --NH--; and A represents an oxygen or sulfur atom.

Process for preparing aminobenzoic acid derivatives

Heterocycle-containing carbonic acid derivatives

Aminobenzoic acid derivatives

An aminobenzoic acid derivative represented by the following formulas (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group; R.sup.3 represents a halogen atom; X represents --O-- or --N--; and A represents an oxygen or sulfur atom.

Naphthalene derivatives of the formula: ##STR1## wherein R.sup.1, represents a hydrogen atom, a lower alkyl group or an acyl group; R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroaryllakyl group; R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group; R.sup.6 is C.sub.1-6 alkyl; and m is 0 or an integer of from 1 to 2 useful in treating autoimmune diseases are disclosed.

Naphthalene derivative

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are useful in the pharmaceutical field, especially in treating allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

1,4-diazepine derivative and its pharmaceutical use

A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##

Glycerin derivative and its pharmacological use

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

Growing community of inventors

Ibaraki, Japan

Isao Yamatsu