Toyama Chemical Co., Ltd.

Isao Watanabe

Joji Nakano

Toru Hiraiwa

Satoshi Ono

Kaishu Momonoi

Katsuyuki Nagumo

Tsutomu Kodama

Hiroyasu Takagi

Norio Abe

Yutaka Kodama

Hiroshi Hirano

Kenji Takeda

Hirotoshi Arai

Takuya Kodama

Hiroyo Kawafuchi

Tomonobu Yamaguchi

Kunikazu Furuhata

Masao Nakabayashi

Makoto Takata

Masaakira Senoura

Mineichi Sudani

Katsufumi Tanaka

Katsunori Tanaka

Akira Takai

A piperazine derivative represented by the following formula or a salt thereof: ##STR1## which is useful for curing cerebro-vascular disease and post-cerebro-vascular disease.

Piperazine derivative or its salt, process for producing the same and

This invention relates to a novel 1,4-dihydropyridine derivative of the formula ##STR1## wherein R2 is pyridyl, or a salt thereof. These compounds have a vasodilating activity and a platelet aggregation inhibiting activity. Also disclosed are pharmaceutical compositions containing the same.

Pyridyl ester containing 1,4-dihydropyridine derivatives and salts

This invention relates to a 1,4-dihydropyridine derivative of the formula ##STR1## wherein Y represents an oxygen or sulfur atom or a vinylene group, Z represents an oxygen or sulfur atom or an alkylene group, R.sup.2 represents an imidazolyl or pyridyl group and the remaining substituents are herein defined. These compounds have a vasodilating activity and a platelet aggregation inhibiting activity.

Vasodilating and platelet aggregation inhibiting 1,4 dihydropyridines

A novel 2-[4-(3-methyl-2-thienyl)phenyl]propionic acid and a pharmaceutically acceptable salt thereof. These compounds are useful for treating symptoms of inflammation and pain in mammals including man. This disclosure relates to such compounds, a process for producing the same, a pharmaceutical composition containing such a compound and a method for treating symptoms of inflammation and pain.

Novel 2-[4-(3-methyl-2-thienyl)phenyl]propionic acid and

Novel sym.-triazines having the formula: ##EQU1## wherein R.sup.1 is a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aralkyl or heterocyclic alkyl group; R.sup.2 is a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or heterocyclic alkyl group; and Z.sup.1 and Z.sup.2, which may be the same or different, each represents oxygen or sulfur, have a central nerve inhibitory activity, an anti-inflammatory activity, an analgesic activity and a sedative activity, and can be prepared by reacting a 2,4-dichloro-6-substituted sym.-triazine with a compound having the formula HO--R.sup.2 in which R.sup.2 is the same as defined above.

Sym.-triazine carbamates

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Toyama, Japan

Isao Watanabe