Otsuka Pharmaceutical Company, Limited

S.t. Chemical Co., Ltd.

Isao Takemura

Makoto Matsumoto

Masatoshi Chihiro

Hiroshi Shimizu

Fujio Tabusa

Toyoki Mori

Motohiro Itotani

Yoshikazu Haraguchi

Yoshikazu Kawano

Hiroshi Yamashita

Muneaki Kurimura

Takayuki Matsuzaki

Takumi Sumida

Kazuyoshi Kitano

Norimitsu Hariguchi

Hisashi Nagamoto

Goro Miyakoda

Shunpei Ishikawa

Yukitaka Uematsu

Shinobu Sueyoshi

Hirofumi Sasaki

Nobuaki Ito

Hidetsugu Tsubouchi

Kunio Oshima

Hironobu Ishiyama

Hideki Kitagaki

Junpei Haruta

Hidetaka Hiyama

Hiroyuki Hashizume

Kenji Watanabe

Yoko Sakamoto

Toshio Shinohara

Yuya Nakai

Yohei Hayashi

Hideki Kawasome

Kazuhiko Fujita

Miki Matsuba

Atsunori Kaneshige

Michiaki Tominaga

Shin Miyamura

Tomoichi Shinohara

Kaoru Abe

Kuninori Tai

Kenji Nakaya

Takahito Yamauchi

Yoshihisa Tanada

Kazuyoshi Nagami

Masanori Kawasaki

Takeshi Hasegawa

Kinue Ohguro

Tatsuo Tomishige

Hiromi Yata

Kazuho Kohashi

Kazuho Tanaka

Mikayo Hayashi

Izuru Nakamura

Xiuhao Chen

The purpose of the present invention is to provide a compound having excellent antibacterial activity against, multidrug-resistant tuberculosis bacteria, and/or non-tuberculous acid-fast bacteria. A compound represented by formula [I]: (in the formula, each symbol is as described in the attached specification), or a salt thereof can be used to diagnose, prevent, and/or treat tuberculosis.

Piperidine derivative

It is an object of the present invention to provide a compound having an excellent antibacterial activity against tuberculosis bacteria, multidrug-resistant tuberculosis bacteria and/or non-tuberculous mycobacteria. Disclosed is a compound of the general formula (1): wherein each symbol is defined as described in the attached specification, or a salt thereof.

Heterobicyclic compounds and their use for the treatment of tuberculosis

The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof,

6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): 

Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-&#x3b1;, and IL-4

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein Ris a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and Ris a group represented by the following general formula: (wherein R's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.

Agent for inhibition of cytokine production and agent for inhibition of cell adhesion

The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1) in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and &#x2014;(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30) and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against, multi-drug-resistant, and atypical acid-fast bacteria. 

2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i) and (ii): (i) &#x2014;CO&#x2014;B&#x2014; wherein B is a Calkylene group and (ii) &#x2014;CO&#x2014;Ba&#x2014; wherein Ba is a Calkenylene group, and include optical isomers and salts of the compounds.

Thiazole compound and use thereof

A stem fog generator () for vehicle aromatic components into a cabin and suitable for use in a vehicle, comprising a plug part () and a steam fog generator body () foldably connected to each other, wherein the plug part () is cylindrically formed so as to be attachable to and detachable from an accessory socket (), a power supply from the plug part () is fed to a heater () through an operating switch (), a loading/unloading.

Steam fog generator for vehicle

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula:

Thiazole derivative

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Naruto, Japan

Isao Takemura