Yamanouchi Pharmaceutical Company Ltd.

Sony Corporation

Astellas Pharma Gmbh

Isao Takahashi

Koji Nagai

Hiroyuki Kojima

Toshio Sasaki

Kenji Abe

Nobuaki Shindo

Takashi Osono

Hiroshi Yamaguchi

Shunichi Watanabe

Yoshihiko Oka

Hiroshi Gushima

Yoh Terada

Masayuki Ishii

Keisuke Murakami

Masamichi Mori

Ken-ichi Suzuki

Harumitsu Imai

Shigenobu Kadota

Koichi Tanaka

Shigeru Miyazaki

Nobuaki Amino

Masatoshi Taniguchi

Takeshi Saito

Ken-ichi Suzumura

Mitsuo Amase

The present invention relates to a novel compound which is useful as an agent for prevention and treatment of diseases associated with HDAC, in particular, tumor or cell proliferative diseases. The depsipeptide compound or its pharmaceutically acceptable salt of the present invention has a good HDAC inhibitory activity and an inhibitory activity of cell proliferation against human cancer cells and, therefore, is useful in treatment and improvement of diseases and pathogenic conditions associated with histone acetylation, in particular, tumor or cell proliferative diseases.

Depsipeptide compound

A composite electronic apparatus consisting of a video and audio signal processing portion including image displaying circuits for displaying images based on a video signal and sound reproducing circuits for reproducing a sound based on an audio signal, a position detecting portion for conducting positional detection to produce position data representing a detected position, a data reproducing portion operative to read information from a record medium and to reproduce map data or video or audio data on the basis of the information read from the record medium, a data processing portion for causing the position data and the map data to be subjected to predetermined data processing, a video signal transmitting portion operative to produce a video signal for image display on the basis of the position data and the map data subjected to the predetermined data processing and to transmit the video signal for image display to the image displaying circuits so that images displayed by the image displaying circuits, and a cabinet for containing the video and audio signal processing portion, a part of the position detecting portion, the data reproducing portion, the data processing portion and the video signal transmitting portion and for supporting another part of the position detecting portion. The audio data reproduced by the data reproducing portion is selectively applied to sound reproduction by sound reproducing circuits in the video and audio signal processing portion.

Portable apparatus for real time video display of location and for

A 7-formylaminocephalosporin compound represented by general formula (I): ##STR1## wherein R.sup.1 represents a carboxy group or an aminocarboxymethyl group ##STR2## R.sup.2 represents a hydrogen atom or a protective group for a carboxy group, and

7-formylaminocephalosporin compounds

A new antibiotic substance, designated Y-G19ZD3, is produced by the fermentation of a newly discovered microorganism Streptomyces organonensis Y-G19Z or a mutant thereof. The antibiotic substance Y-G19ZD3 is effective against gram negative bacteria and is useful also as an intermediate for the production of other antibiotics.

Antibiotic Y-G19Z D3 and the production thereof

Growing community of inventors

Saitama, Japan

Isao Takahashi