Mitsui Toatsu Chemicals, Incorporated

Mitsui Toatsu Kagaku Kabushiki Kaisha

Mitsui Toatsu Kagaki Kabushiki Kaisha

Mitsui Toatsu Kaguku Kabushiki Kaisha

Isao Sakano

Akira Awaya

Yutaka Okazaki

Hiroshi Tokuda

Takuo Nakano

Hiroshi Kawazura

Tatsuro Yokoyama

Mikio Kumakura

Seitaro Kajiya

Yoshitsugu Yamada

Shiyoichiro Miyahara

Tamotsu Minami

Kajiya Seitaro

Disclosed are 2-thiazol derivatives having the general formula ##STR1## where R.sub.1 and R.sub.2 independently represent lower alkyl radicals having 1 to 4 carbon atoms and X represents a lower alkyl radical, a lower alkoxy radical, a lower alkoxycarbonyl radical, a halogenoalkoxy radical, a radical of the formula ##STR2## or a radical of the formula ##STR3## Also disclosed are a process for preparing the derivatives and pharmaceutical compositions having immunomodulatory activity which comprise the derivatives as the active ingredient.

2-Thiazolamine derivatives, process for preparing same, and

Uracil derivatives, process for preparing same, and pharmaceutical

N-(4-Phenyl-2-thiazolyl)carbamate derivatives

Thiazole compounds, a process for preparing same and a pharmaceutical

Thiazolylurea derivatives, a process for preparing same and a

The present invention relates to a piperazine compound represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen atom or a phenyl group, R.sup.1 stands for a hydrogen atom or an alkyl group, and R.sup.2 stands for a hydrogen atom or an alkyl group. These compounds are valuable as immunopotentiators, such as for the treatment of chronic rheumatoid arthritis and other diseases accompanied by reduction or abnormal change of the immune function.

2-Substituted thiazolyl-piperazine compounds, process for preparation

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Yokohama, Japan

Isao Sakano