Taiho Pharmaceutical Company Limited

Kabushiki Kaisha Toshiba

Toshiba Ave Co., Ltd.

Isao Miyazaki

Tadashi Shimamura

Hidenori Fujita

Masanori Kato

Satoru Iguchi

Masahiro Takahashi

Shinichi Ooi

Wataru Kuroiwa

Yasushi Odagiri

The present invention provides a novel RET inhibitor comprising, as an active ingredient, a compound or a salt thereof that have not been known for their RET inhibitory activity, and also provides an agent for preventing or treating diseases (e.g., malignant tumors) that can be prevented or treated by RET inhibitory activity. The RET inhibitor comprises, as an active ingredient, a compound represented by Formula (I) below or a salts thereof: wherein A, Rto R, X, and n are as defined in the specification.

Fused pyrimidine compound or salt thereof

The problem to be solved by the present invention is to provide a novel compound having RET inhibitory activity. The present invention also provides a pharmaceutical preparation that is useful for the prevention and/or treatment of RET-related diseases, particularly cancer, based on RET inhibitory activity. The present invention provides a compound represented by Formula (I): wherein A, R, and X are as defined in the specification; or a salt thereof.

The present invention provides a novel RET inhibitor comprising, as an active ingredient, a compound or a salt thereof that have not been known for their RET inhibitory activity, and also provides an agent for preventing or treating diseases (e.g., malignant tumors) that can be prevented or treated by RET inhibitory activity. The RET inhibitor comprises, as an active ingredient, a compound represented by Formula (I) below or a salts thereof:  wherein A, Rto R, X, and n are as defined in the specification.

A remote control system which can control a plurality of remote control units (RCUs). The remote control system includes a first memory for storing an RCU identification code for each of the remote control units, a second memory for storing a maker identification code for the remote control apparatus corresponding to the RCU identification code, a model code, and a remote control code. The system further includes a device for reading an active remote control code from the second memory on the basis of the RCU identification code read from the first memory according to the apparatus control request from an active remote control unit. Electromagnetic waves or infrared rays act as a second modulated wave which is modulated on the basis of the active remote control code in order to control the function of the remote control apparatus corresponding to the active remote control code. The plurality of remote control units are managed by a single remote control reception and processing device.

Remote control system in which a plurality of remote control units are

There is provided a method with which the expansion of CATV services and the diversity of subscribers' needs can be dealt with flexibly, it is easier to maintain and expand the apparatus, the system can be operated simply, and the parental control function is also simple. A head end and a subscriber terminal unit have two-way communication means and are connected to each other via a two-way transmission line. The HIB and subscriber remote control units each have two-way communication means. The output of HIB is supplied to various types of apparatuses. The HIB can also exchange data with an expansion unit. To control various types of apparatuses with a remote control unit, the remote control unit communicates with the HIB, receives the necessary data under the control of HIB, and together with HIB, controls various types of apparatuses.

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Tsukuba, Japan

Isao Miyazaki