Sumitomo Chemical Company, Limited

Other

Toyoda Gosei Co., Ltd.

Isao Kurimoto

Masayoshi Minai

Takayuki Higashii

Shoji Toda

Koichi Fujisawa

Takeshi Tani

Hideki Ushio

Chizu Sekine

Norihiko Hirata

Chizu Kawakami

Miyuki Oikawa

Kiyoshi Imamura

Hiroshi Ueda

Akihiko Nakamura

Tetsuo Yamaguchi

Naoki Inui

Takashi Miki

Akio Kurihara

Yuichiro Aratake

Shinichi Yachigo

Toshiya Takahashi

Tadanobu Iwasa

Shinzo Seko

Masahiko Mizuno

Hideo Nagasaki

Kazunori Iwakura

Naoyuki Takano

Kohji Yamatsuta

Yasunobu Miyamoto

Kazuhiro Yamauchi

Hiroki Yamamoto

Tadashi Mizuno

Yukihiro Honda

Tamio Hayashi

Masaki Ohashi

Hitoshi Murotani

Shigeaki Chika

Takayuki Higashi

Masataka Sasayama

Takahiro Yamamoto

Yasuhiro Uozumi

Yuki Takekawa

A process for preparing an optically active biaryl compound the formula (4): which comprises reacting an aromatic sulfonic acid ester compound of the formula (1): with an organic boron compound of the formula (2): at 70&#xb0; C. or below in the presence of a nickel catalyst and a base. The biaryl compounds produced using this process possess a high optical purity and are useful as intermediates for medicaments, agrochemicals, etc.

Process for preparing a biaryl compound

A method for producing (S)&#x2014;N-protected-propargylglycine of the following formula (2), wherein the method comprises asymmetrically hydrolyzing an N-protected-propargylglycine ester of the following formula (1) by using an asymmetric hydrolysis enzyme or a cultured substance of a microorganism having an ability of producing this enzyme or a treated substance thereof. The hydrolysis enzyme is obtained from a microorganism selected from the group consisting ofgenus,genus,genus,genus,genus,genus,genus,genusgenus andgenus.

Method for producing optically active N-protected-propargylglycine

There is provided a production method for producing a biarylalanine compound of formula (4): wherein Rrepresents a amino protective group and Rrepresents an amino protective group or a hydrogen atom, Ris a carboxy protective group, or the like, andRis a substituted or unsubstituted aryl or heteroaryl group, characterized by reacting an aromatic amino acid of formula (1) wherein X is a halogen atom or a trifluoromethanesulfonyloxy group, and R, Rand Rhas the same meaning as defined above, with an organic boron compound of formula (2): wherein Rhas the same meaning as defined above, and Qand Qare the same or different and each is a hydroxy group, an alkoxy group having 1 to 4 carbon atom(s), in the presence of nickel catalyst and a base.

Production method for biarylalanine

There is disclosed an advantageous mixed acid anhydride production method of formula (1):RC(O)OY(O)(R)&#x2003;&#x2003;(1)wherein R, Rand Y denote the same as defined below, n and p denote an integer of 1 or 2, which is characterized by adding a carboxylic acid of formula (2);RCOOH&#x2003;&#x2003;(2)wherein Rdenotes a hydrogen atom, an optionally substituted alkyl group or the like, an organic base to a solution of a carboxylic acid activating agent of formula (3);(R)Y(O)X&#x2003;&#x2003;(3)wherein Rdenotes an optionally substituted aliphatic hydrocarbyl group or the like, Y denotes a carbon atom, a phosphorus atom, or a sulfur atom, and X denotes a chlorine atom or the like.

Production of mixed acid anhydride and amide compound

There are disclosed imine compounds of formula (7) and (11), and processes for preparing the same:

Process for producing optically active 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid, and salt thereof

Process for producing 2-alkylidene-4-bromoacetoacetic acid ester

Process for producing optically active 3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic acid, and salt thereof

Producing Z-isomer of hydrogen bromide salt of 2-aminothiazole derivative

A process for producing a purified aryl vinyl sulfone solution, characterized in that an aryl vinyl sulfone is crystallized from an organic solvent solution of a crude aryl vinyl sulfone to give a crystallization mixture, and a wet cake of the aryl vinyl sulfone obtained by the separation of the solution from the said mixture is dissolved in a solution-forming solvent selected from ethers of 4 to 8 carbon atoms, aromatic hydrocarbons of 6 to 10 carbon atoms, halogenated hydrocarbons of 1 to 6 carbon atoms, ketones of 3 to 8 carbon atoms, esters of 3 to 6 carbon atoms, and nitrites of 2 to 6 carbon atoms.

Process for producing aryl vinyl sulfone solution and use thereof

There is disclosed a method for producing an essentially enantiomerically pure N-protected-azetidine-2-carboxylic acid of formula (1):

Methods for producing N-protected-azetidine-2-carboxylic acids

There are disclosed a process for producing the optically active cyclic amino acid ester derivative of the formula (I):

Optically active cyclic amino acid ester derivatives and processes for producing the same

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Suita, Japan

Isao Kurimoto