The University of Tokyo

Iatron Laboratories Inc.

Perseus Proteomics Inc.

Hogy Medical Co., Ltd.

Chiome Bioscience Inc.

Mitsubishi Kagaku Iatron, Inc.

Isao Kohno

Hiroko Iwanari

Hiroyuki Aburatani

Gilbu Soe

Takao Hamakubo

Yumiko Ito

Kimiko Inuzuka

Yukio Ito

Akira Sugiyama

Takashi Tanaka

Tatsuhiko Kodama

Hidetaka Seo

Hajime Fujii

Takashi Nakagawa

Isao Ohnishi

Yoshio Jo

Ken Fukushi

Toshimitsu Momose

Hirotaka Itoh

Koji Tanabe

Michiyo Tanaka

Mami Shiiba

Yuri Koyama

Keisuke Kosake

Koji Maemura

Kumiko Taniguchi

Toshiko Sakihama

Yoshitaka Kumakura

Naoto Harigai

Yukiko Banzai

Chika Koyama

Shoko Ishida

Donghui Li

Shu-ichi Hashimoto

Hiroshi Nishioka

Gen-Ichiro Nonaka

Koji The University Of Tokyo Maemura

Disclosed is a method for producing an antibody directed against a protein, particularly a transmembrane protein, expressed on the surfaces of cells. Specifically disclosed is a means for obtaining a desired antibody by mixing cells capable of expressing an antigen protein on the surfaces thereof (i.e., antigen molecule-expressing cells) with an antibody library composed of antibody-expressing cells, viruses or the like, and subsequently concentrating/isolating only components (e.g., antibody-expressing cells, viruses) capable of binding to the antigen molecule-expressing cells from the components (e.g., antibody-expressing cells, viruses) of the antibody library.

Method for producing antibody directed against protein expressed on cell surface

The present invention provides a novel diagnostic or therapeutic method for pancreatic cancer employing a blood marker. The present invention provides a diagnostic or therapeutic drug for pancreatic cancer containing an anti-AMIGO2 antibody.

Diagnostic agent and therapeutic agent for pancreatic cancer

To provide a method of determining vasculopathy, which is a risk factor of myocardial infarction, angiopathic dementia, etc., at an early stage thereof (i.e., mild vasculopathy). The present invention provides a method of determining the severity of mild vasculopathy, including determining PTX3 level in an assay sample by use of an anti-PTX3 monoclonal antibody.

Method of measuring PTX3 with high sensitivity

It is an object of the present invention to provide a novel antibody capable of specifically recognizing ROBO1 that is expressed in a cell membrane, a hybridoma that produces the above antibody, a method for producing the above antibody, and a tumor diagnostic agent used in PET comprising the above antibody. The present invention provides a monoclonal antibody capable of specifically recognizing ROBO1 existing on the surface of a cell, which is obtained by immunizing an animal to be immunized with a ROBO1-displaying budded baculovirus recovered from the culture supernatant of host cells infected with a recombinant baculovirus comprising the full-length cDNA of ROBO1 as an antigen.

Tumor diagnostic agent used in PET comprising anti-ROBO1 antibody

An absorptive wound covering protecting material and a method for preparing an absorptive wound covering protecting material are characterized by solidifying a sponge raw solution containing no reinforcement that is obtained by mixing viscose and crystalline mirabilite as main raw materials, or a sponge raw solution obtained by mixing viscose containing a reinforcement comprising natural fibers having a length of at least 5 mm to 40 mm, and crystalline mirabilite as main raw materials, by performing a heat treatment on the sponge raw solution, and then forming the solidified cellulose sponge in a thickness somewhat greater than a desired thickness, and then forming the cellulose sponge in a sheet form having a desired thickness by compressing the cellulose sponge, and, if required, carboxymethylating hydroxyl groups in a glucose unit constituting a cellulose sponge so that a degree of substitution of the hydroxyl groups is from 0.5 to less than 1.0, and then, forming an incision the cellulose sponge.

Absorbable protective coatings for wound with the use of cellulose sponge and process for producing the same

Monoclonal antibody and method of immunological analysis of e-D-dimer

Anti-human plasmin-.alpha..sub.2 -plasmin inhibitor complex antibodies,

Anti-human soluble fibrin antibody, hybridoma, and immunoassaying method

Monoclonal antibodies specifically reacting with the side face of a C-reactive protein (CRP), i.e., monoclonal antibodies specifically reacting with the side face of a disk-like subunit of a C-reactive protein (CRP), hybridoma producing the monoclonal antibody, and methods for the use thereof are disclosed.

Hybridomas producing monoclonal antibodies specific for C-reactive

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Tokyo, Japan

Isao Kohno