Shimadzu Corporation

Isao Katasho

Tetsuo Ohashi

Tokuji Ikeda

Mitsugi Senda

A chip device for manipulating an object component is described, in which multiple liquid substances such as reagents required for a series of manipulations on a sample are stably secured in separated states throughout the manipulations within the device. The chip device includes a manipulation chip, magnetic particles, and a magnetic field application means. The manipulation chip includes a substrate, a groove formed in the surface of the substrate, and a manipulation medium accommodated in the groove such that gel phases and aqueous liquid phases are alternately disposed in the longitudinal direction of the groove and are in contact with each other. The magnetic particles are for capturing and carrying the object component. The magnetic field application means is capable of moving the magnetic particles in the longitudinal direction of the groove in the substrate by the application of a magnetic field to the substrate.

Chip device for manipulating object component, and method using the same

An enzyme electrode composed of a carrier, an enzyme immobilized on a parr of the surface of the carrier, a coating film consisting of a thin film coating the portion where the enzyme is immobilized and being permeable for the substrate for the enzyme and an internal electrode capable of applying voltage to the surface where the enzyme is immobilized, said carrier being impregnated with a substance which acts as an electron transfer mediator, which is useful for measurement of concentration of the substrate in vital samples such as blood serum, blood plasma, urine etc.

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Kyoto, Japan

Isao Katasho