Japan Atomic Energy Research Institute

Tokyo Optical Company, Ltd.

Other

Mitsubishi Gas Chemical Company, Inc.

Takeda Chemical Industries, Inc.

Shindengen Electric Manufacturing Company Limited

Senju Pharmaceutical Co., Ltd.

Yamanashi Electronics Co., Ltd.

Japan Immunoresearch Laboratories Co., Ltd.

Takeda Chemical Indus., Ltd.

Kabushiki Kaisha Tokyo Contact Lens Kenkyusho

Tokyo Optical Company Ltd. (kabushiki Kaisha Tokyo Megane)

Tokyo Contact Lens Research Institute

Keizo Shida

Isao Kaetsu

Masaru Yoshida

Minoru Kumakura

Hiroshi Okubo

Masaharu Asano

Akihiko Ito

Masamichi Kato

Katsuyuki Nakai

Hidetoshi Yamanaka

Fumio Yoshii

Masao Tamada

Noboru Kasai

Koichiro Hayashi

Hidenari Suyama

Nobuo Kameda

Akira Shiraishi

Yuji Maeda

Masakazu Adachi

Goro Shimaoka

Akira Ohtori

Yasushi Morita

Masahiro Horigome

Hiroshi Watanabe

Yoshihide Komaki

Tsuneo Isomura

Tadaichi Murata

Tomotaro Sato

Ryuji Arai

Masanobu Urabe

Minoru Kumkaura

Tomio Yoneyama

Mieko Suzuki

Yasuji Sejima

Hisako Yuasa

Takashi Ohno

Toshiyuki Itoh

Hideo Kohyama

Hideo Koyama

Minoru Kamakura

Shigeru Yamanaka

Hideo Kouyama

Tsutomu Sakurai

An electroresponsive hydrogel produced by alkali hydrolysis of a copolymer comprising N-isopropylacrylamide, an ionic monomer and a crosslinking agent; and a physiologically active substance release control system comprising a biosensor, an amplifier and an electroresponsive hydrogel containing physiologically active substance are disclosed. The hydrogel of the present invention is capable of releasing a physiologically active substance alone in an amount corresponding to the applied voltage with excellent reproducibility by contracting and reswelling in good response to the loading and unloading of an external stimulation voltage, it can be advantageously used in a physiologically active substance release control system capable of releasing an essential physiologically active substance in a necessary amount according to changes in physiological conditions. Also, the physiologically active substance release control system of the present invention using this hydrogel is useful for the treatment of various diseases including diabetes mellitus.

Electroresponsive hydrogel and physiologically active substance release

In order to make hard and soft contact lenses having a pore diameter and a pore density optimum for use as oxygen permeable contact lenses, the contact lens after molding is subjected to irradiation of a polyvalent heavy ion beam having a mass number of 2 to 100 (preferably 10 to 80) and an ion energy of 10M eV (preferably 50M eV) or higher, at an ion radiation density of 10 to 10.sup.9 ions/cm.sup.2 (preferably 10.sub.2 to 10.sub.5 ions/cm.sup.2) and thereafter ultrasonically etched (preferably at 10 to 50 MHz) at a temperature of 4 to 50.degree. C. (preferably 10.degree. to 30.degree. C.) in the presence of chloroacetic acid (preferably tricholoracetic acid).

Porous contact lens and method for making it

A carrier for immobilization of microorganisms is prepared by impregnating a fabric such as cotton gauze having a mesh size of 10-50 with 20-50% by weight of a vinyl monomer such as ethlene glycol methacrylate and polymerizing the monomer with ionizing radiation to form a polymer coating on the fabric. A microorganism such as Trichoderma reesei is grown in a liquid culture medium in contact with the polymer-coated fabric and the polymer-coated fabric is recovered containing growing cells of the microorganism. The polymer-coated fabric has high air permeability and permits good diffusion of liquid culture medium.

Immobilization of growing microorganisms on polymer-coated cotton gauze

An electrophotographic photoreceptor comprises an electrically conductive support, a photoconductive layer provided thereon, and a protective layer coated on the photoconductive layer, wherein the protective layer comprises a product of uncatalized hydrolysis of a composition essentially consisting of at least one specific epoxysilane compound, at least one specific alkylalkoxysilane compound, and at least one specific aminosilane compound. The photoreceptor is very useful in that it is free from wear due to friction with paper and cleaning members, keeps high resolving power, and is sufficiently proof against continuous copying under conditions of high temperature and high humidity.

Electrophotographic photoreceptor

Hydrophilic monomers in a supercooled, transparent state, are polymerized in the presence of water. The polymers have low levels of residual monomers and exhibit good mechanical strength. The process provides materials useful as contact lenses.

Method of manufacturing soft contact lens material

A mixture of a specified siloxanylalkyl ester monomer and a specified vinyl monomer is polymerized by exposure to an ionizing radiation at low temperatures and the resulting polymer is worked with a lathe cut to form a contact lens. The contact lens obtained is free from any optical distortion, has good dimensional stability and exhibits high oxygen permeability. In a preferred embodiment, a monomer mixture comprising a siloxanylalkyl ester, a methacrylate or acrylate, N-vinylpyrrolidone, and a small amount of a dimethacrylate or diacrylate is exposed to a total dose of 1.times.10.sup.5 -5.times.10.sup.6 roentgens at a low temperature (-80.degree. C. to -20.degree. C. and at a dose rate of 8.times.10.sup.4 -2.times.10.sup.6 roentgens per hour, and the resulting polymer is worked into a contact lens by a suitable forming process involving cutting, grinding and polishing operations.

Process for producing a contact lens

A slow-release composite having pyroglutamyl-histidyl-triptophyl-seryl- tyrosyl-D-leucyl-leucyl-arginyl-proline ethylamide or a salt thereof encapsulated in a polymer matrix and a process the same are herein disclosed.

Slow-release composite and process for producing the same

The efficiency of enzymatic saccharification and fermentation of cellulose in a waste cellulose resource can be increased by a preliminary treatment with ionizing radiation. This irradiation of the waste cellulose resource can be accelerated by the preliminary addition of an aqueous alkali solution.

Method of pretreatment in saccharification and fermentation of waste

A slow-release composite having pyroglutamyl-histidyl-triptophyl-seryl-tyrosyl-D-leucyl-leucyl-arginyl-pro line ethylamide or a salt thereof encapsulated in a polymer matrix and a process the same are herein disclosed.

An Estracyt compound having a carcinostatic bound thereto is obtained by reacting an Estracyt compound with a carcinostatic having one or more radicals selected from among COOH, Cl, NH.sub.2 and OH, either directly or after reaction with an amine to replace one or both Cl groups in the nitrogen mustard portion in the Estracyt compound with a NH.sub.2 group, in the presence or absence of a catalyst. The resulting compound is more effective in cancer control than the Estracyt compound associated substance.

Process for preparing Estracyt compounds having a carcinostatic bound

A process is, herein disclosed, for producing a slow release composite having a physiologically active substance encapsulated therein, which comprises preparing a system wherein one or more physiologically active substances are in contact with protein from one or more protein sources, and bringing said system into direct contact with steam at temperatures between 50.degree. C. and 100.degree. C. to denature the protein and make the same hydrophobic, to thereby make a slow release composite having the physiologically active substance dispersed, fixed and encapsulated therein. And a process is also disclosed for producing a slow release composite which comprises preparing a mixture of one or more hydrophilic polymerizable monomers containing the body fluid and/or isotonic solution, protein from one or more protein sources, and one or more physiologically active substances, subjecting the mixture to direct contact with steam and irradiation with light or ionizing radiation, said treatment with steam being performed either before or simultaneously with irradiation with light or ionizing radiation.

Process for producing a slow release composite

A fine particulate carrier for use in clinical testing which has a size of 0.5 to 20 microns and a process for producing thereof are herein disclosed.

Fine particulate for use in clinical testing and a process for producing

A process is herein disclosed for producing a slow release composite comprising grinding and mixing mechanically in a frozen state one or more polypeptides, one or more proteins and one or more physiologically active substances shaping the blend into a desired form and compressing at a pressure of from 100 to 20,000 kg/cm.sup.2 to thereby produce a slow release composite having the physiologically active substances encapsulated therein.

A polymer composition containing a physiologically active substance which can be released at a controlled rate is prepared by contacting one or more polymerizable monomers with the physiologically active substance, making the monomers into a specific shape and then irradiating the shaped article with light or an ionizing radiation at a low temperature below room temperature to polymerize the polymerizable monomers.

Process for preparing a polymer composition

A physiologically active substance controlled release composite composition is prepared by a process which comprises the steps of:

Process for preparing a physiologically active substance controlled

Growing community of inventors

Takasaki, Japan

Isao Kaetsu