Fujisawa Pharmaceutical Company, Ltd.

Okayama University

Isao Date

Shigeki Ono

Masahiro Nishibori

Shuji Mori

Hideo Takahashi

Yasuko Tomono

An objective of the present invention is to provide a cerebral vasospasm inhibitor which is effective on cerebral vasospasm occurring after subarachnoid hemorrhage and has few side-effects. The cerebral vasospasm inhibitor of the invention is characterized in containing an anti-HMGB1 monoclonal antibody as an active ingredient.

Method of preventing cerebral vasospasm with anti-HMGB1 antibody

A brain-protective agent containing an NF-&#x3ba;B decoy. In brain diseases, the brain can be particularly effectively protected against brain disorders (for example, cerebral vasospasm following a subrachnoidal hemorrhage and apoptosis of the nerve cells following a cerebrovasucular accident or serious head injury) caused by the undesired activation of cytokines or cell adhesion factors which are regulated by NF-&#x3ba;B by administering the brain-protective agent containing an NF-&#x3ba;B decoy, i.e., acompound antadonistic specifically to a nucleic acid to which NF-&#x3ba;B binds.

Brain-protective agent

Growing community of inventors

Okayama, Japan

Isao Date