Ajinomoto Co., Ltd.

Mochida Pharmaceutical Co., Ltd.

Isao Arai

Takashi Yamamoto

Hirokazu Naora

Kazuo Kato

Kazuhiro Watanabe

Hiroyuki Matsueda

Masanobu Yatagai

Kimihiro Murakami

Masaki Naito

Husayoshi Kakizaki

The present invention relates to a novel process for preparing an aminostilbene derivative, which is important as an active component of anticancer drugs or an intermediate for preparation thereof, as well as methods of producing the same.

Process for preparing aminostilbene derivatives

A process for producing piperidinecarboylic acid amide derivatives useful as serotonin antagonists, antithrombocytic agents or intermediates for them, which comprises the step of reacting a 2-oxazoline compound with a piperidine derivative in the presence of an acid is provided. This process is an industrially excellent process for producing piperidinecarboylic acid amide derivatives useful as serotonin antagonists, antithrombocytic agents or intermediates for them.

Process for producing piperidinecarboxylic acid amide derivatives

Reaction of a 7-aminocephalosporanic acid with a carboxylic acid in the presence of a dehydration condensing agent and an acid or acid complex provides the corresponding amide in high yield and high purity.

Process for preparing cephalosporin compounds

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Kawasaki, Japan

Isao Arai