Otsuka Pharmaceutical Factory, Inc.

Takeda Chemical Industries, Inc.

Mitsui Chemicals, Inc.

Isamu Tateishi

Fujio Inoue

Tatsuro Tsuruoka

Akihito Togawa

Hitoshi Mori

Yasushi Morimoto

Hidekatsu Shoji

Ryoji Mori

Nobuaki Sumiyoshi

Hideshi Okamoto

Yasushi Nagata

Kouichi Igarashi

Sadamu Shirokuma

Takayuki Hagiwara

Tetsuya Hatono

Yoshiki Maesaki

Kenji Konishi

Kazunari Yoshikawa

Rie Ishii

A reduced-dissolved-oxygen-content drug solution produced by filling and sealing the drug solution in a drug solution container () formed of a plastic material having an oxygen permeability of not lower than 200 cm/m&#xb7;24 h&#xb7;atm at 25&#xb0; C. at 60% RH within 12 hours after a steam sterilization process or a hot water sterilization process and having a steady-state oxygen permeability of not higher than 100 cm/m&#xb7;24 h&#xb7;atm at 25&#xb0; C. at 60% RH, subjecting the drug solution container to the steam sterilization process or the hot water sterilization process, and storing the drug solution container in an environment having deoxidization means for reducing the dissolved oxygen concentration of the drug solution to not higher than 2 ppm when the oxygen permeability of the plastic material reaches the steady-state level.

Drug solution having reduced dissolved oxygen content, method of producing the same and drug solution containing unit having reduced dissolved oxygen content

A method for reinforcing a weak sealed portion of a multi-chamber medical container by simple processing. The method for reinforcing a weak sealed portion of a multi-chamber medical container includes a multi-chamber container forming step for forming a multi-chamber medical containerincluding a first container portionfor containing a medicine, a second container portionfor containing a medical solution, an empty container portion, a pair of lateral side strong sealed portionsfor forming both side ends of the container portions, a medical solution side weak sealed portionfor forming a partition between the first container portionand the second container portion, and a discharge side weak sealed portionfor forming a partition between the first container portionand the empty container portion; and a weak sealed portion reinforcing step for bonding a reinforcement filmfor reinforcing the discharge side weak sealed portionso as to cover the surface of the first container portionand so as to be spaced in the discharge directionfrom a first borderwith the first container portionon the discharge side weak sealed portion

Method for reinforcing weak sealed portion of multi-chamber medical container

In a multilayer film including a first layer (), a second layer (), a third layer (), a fourth layer () and a fifth layer () stacked in this order, the first layer () is composed of a propylene-ethylene random copolymer and/or a polypropylene homopolymer, and the second layer () and the fourth layer () are each composed of a mixture of a propylene-ethylene random copolymer and an &#x3b1;-olefin elastomer. The third layer () is composed of a mixture of a polycycloolefin and polyethylene, and the fifth layer () is composed of a mixture containing a polypropylene homopolymer and a propylene-ethylene random copolymer in a weight ratio of 90:10 to 10:90. A container is formed of the multilayer film with an outer layer and an inner layer thereof being defined by the first layer () and the fifth layer (), respectively.

Multilayer film and container

It is an object of the resent invention to provide a multi-chamber container that has a weak seal portion having an increased joining strength and being easy to be opened when in administration of medicine, and that is provided at low cost. The multi-chamber container includes a medicine accommodation chamber, a diluting solution chamberjointed to one side of the medicine accommodation chambervia a partitioning weak seal portion, an unoccupied chamberhaving a portand joined to an opposite side of the medicine accommodation chambervia a discharging weak seal portion, a film memberattached to the medicine accommodation chamberfor increasing a joining strength of each of the discharging weak seal portionand the discharging weak seal portion, the discharging weak seal portionhaving an easy-to-open portionthat enables the discharging weak seal portionto easily opened therethrough.

Multi-chamber container

A drug solution container package, which can restrain degradation of a drug solution, proliferation of microbes, etc. accompanying the transmission of oxygen in a high degree while maintaining characteristics required of plastic drug solution containers such as heat resistance, impact resistance, pliability, transparency, and resistance against elution of plastic forming material, and to provide a method for manufacturing the drug solution container package. A drug solution is first contained and sealed in a plastic drug solution container having an oxygen gas transmission rate (25&#xb0; C., 60% RH) of not less than 200 cm/m&#xb7;24 h&#xb7;atm within twelve hours after being subject to steam or hot water sterilization, and having an oxygen gas transmission rate (25&#xb0; C., 60% RH) of not more than 100 cm/m&#xb7;24 h&#xb7;atm when the oxygen gas transmission rate is in a steady state, and thereafter the plastic drug solution container is steam sterilized or hot water sterilized and then contained and sealed along with an oxygen scavenger in an outer pouch having an oxygen barrier property.

Drug solution container package and method for manufacturing the same

A drug container of a multilayer film including a first layer () composed of a linear ethylene/&#x3b1;-olefin copolymer having a density of 0.930 to 0.950 g/cm, a second layer () and a fourth layer () each composed of a mixture containing a linear ethylene/&#x3b1;-olefin copolymer having a density of 0.860 to 0.920 g/cmin a weight ratio of 95:5 to 40:60, a third layer () composed of a polycycloolefin, and a fifth layer () composed of a mixture containing a polyethylene and a polypropylene, the fifth layerserving as an innermost layer.

Drug container and multilayer film

Provided a port member for an infusion solution bag that is capable of suppressing occurrence of gaps or wrinkles in a sealed portion in a manufacturing process, and preventing damages to resin sheets of a bag body during storage or transportation. A port member for an infusion solution bag includes a tubular body portion having one end sealed by a plug member structured to enable a hollow needle to be pierced into the plug member, and a tubular to-be-sealed portion continuously formed with an other end of the body portion and having an inner space communicated with the inside of the body portion, the to-be-sealed portion being held between and sealed to end portions of resin sheets overlapped together to form a bag body having an inner space for accommodation of at least a medicine, in which the to-be-sealed portion thus sealed has a radially flattened shape.

Port member for infusion solution bag, and infusion solution bag

A pliable plastic film according to the present invention comprises a heat sealable sealing layer, wherein the sealing layer is made of a mixture of a propylene-&#x3b1;-olefin random copolymer having a crystalline melting point Tof 135 to 145&#xb0; C. and a polypropylene (PP) homopolymer having a crystalline melting point Tof higher than 160&#xb0; C.

Pliable plastic film and container using the same

Medical tubes are well balanced in transparency, flexibility, heat resistance, scratch resistance and rubber elasticity. The medical tubes including a propylene polymer composition (A) that contains a polymer with propylene units, at least part of the polymer having an isotactic structure and the total of the propylene units of the polymer being in an amount of 65 to 82 mol % (the total of the structural units of the polymer in the composition is 100 mol %), and that satisfies the following (a1), (a2) and (b1):

Medical tubes

An object of the present device is to provide a cover capable of preventing the administration of unmixed medicaments to a patient. The cover for being mounted on a multi-compartment infusion bag of the present device is a cover for being mounted on a multi-compartment infusion bag including a plurality of compartments partitioned by at least one easily peelable partitioning seal portion which is opened in response to an increase in the internal pressure of at least one of the plurality of compartments induced by pressing said at least one of the plurality of compartments. The cover has a pair of pinch members that pinch at least one of the plurality compartments. The pair of pinch members has engaging elements that engage each other to maintain a pinching state of the pair of pinch members until the pinching state is released in response to an increase in the internal pressure of said at least one of the compartments so that the suspension portion can be used. The pair of pinch members cover a suspension portion in the pinching state for preventing the use of the suspension portion for suspending the infusion bag until said at least one easily peelable sealing partition is opened.

Cover for being mounted on a multi-compartment infusion bag

The object of the present invention is to provide a gas barrier film suitable for medical uses, which is excellent in gas and vapor properties and can prevent ingredients of an adhesive and the like from eluting even after heating and sterilizing treatment, and a medical bag using the gas barrier film. A medical gas barrier film of the present invention comprises a multilayer gas barrier filmincluding a deposition oriented polyester layerhaving a deposited layerof an inorganic oxide on one surface, an oriented polyamide layeradhered to the surface of the deposited layerand a polyethylene layeradhered to the surface on the opposite side to an adhered surfaceof the oriented polyamide layer, and a multilayer substrate filmincluding a cyclic olefin polymer layer, an elastomer layersand a heat sealing layer, and the multilayer substrate filmis adhered to an other surfaceon the opposite side of the deposited layer of the deposition oriented polyester layer

Growing community of inventors

Naruto, Japan

Isamu Tateishi