Toyama Chemical Co., Ltd.

Handi-pac, Inc.

Isamu Saikawa

Shuntaro Takano

Takashi Yasuda

Hiroyuki Imaizumi

Kaishu Momonoi

Chosaku Yoshida

Yutaka Kodama

Hisatsugu Tsuda

Shohachi Murakami

Takihiro Inaba

Seietsu Kuroda

Masaru Tai

Takako Hori

Ryuko Takeno

Isamu Takakura

Hiroshi Sakai

Hiroshi Sadaki

Hideo Taki

Okuta Takashima

Miwako Komatsu

Jun Nitta

Hirokazu Narita

Yasuo Watanabe

Kiyoshi Tanaka

Yoshinori Konishi

Joji Nakano

Yasuo Kiba

Hirokazu Ochiai

Sumiko Kishimoto

Toyoo Maeda

Masahiro Takahata

Kenshin Hayashi

Chiaki Kutani

Kenji Takeda

Hisashi Minami

Seishi Morita

Tatsuo Hirakawa

Kenzo Tamai

Masatoshi Sugita

Yoshiko Yamamoto

Yozo Todo

Susumu Mitsuhashi

Isao Myokan

Shinzaburo Minami

Isao Kitayama

Hideyoshi Nagaki

Takashi Nagai

Mikako Miyajima

Yoshikazu Fukuoka

Yutaka Takashita

Michiko Mae

Bunei Nagahashi

Tetsuo Yamafuji

Yoshiharu Murotani

Katsuyuki Nagumo

Tetsuya Kajita

Akira Yotsuji

Hirohiko Fukuda

Hidetada Mikami

Junichi Yoshida

Toshinori Ohashi

Noboru Takagawa

Hiroyasu Takagi

Yasuyuki Suzuki

Mikio Kawabata

Akiko Takagi

Shunjiro Misumi

Nobuyuki Matsubara

Yoriko Nagai

Mariko Hayashi

Narita Hirokazu

Takako Wakamiya

Kyoko Kasuya

Fumihiko Iino

Masuru Tai

Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: ##STR1## wherein A represents a group of the formula, --CH.sub.2 -- or a group of the formula ##STR2## in which R.sup.5 represents a hydrogen atom or an alkyl group, and the bond.about.represents syn or anti isomer or their mixture; R.sup.3 represents a hydrogen or halogen atom; and R.sup.4 represents a hydrogen atom or an amino group which may be protected or substituted. These cephalosporins have a broad antibacterial spectrum, are stable against .beta.-lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally.

Cephalosporins, process for producing the same, intermediates thereof

The process for producing bischoline-disulfonate derivatives of Formula (I) ##STR1## useful for enhancing the digestive function comprising reacting, in the presence of an organic solvent, a trimethylammonium salt derivative of Formula (II) ##STR2## wherein R.sup.1 and R.sup.2 are individually lower alkyl and X is a group removable by a disulfonic acid of Formula (III)

Novel process for producing bischoline-disulfonate derivatives

This invention relates to a novel pyridone carboxylic acid derivative having a substituted or unsubstituted cyclopropyl group at the 10-position of pyridobenzoxazine, pyridobenzothiazine or pyridoquinoxaline and a salt thereof, a process for the production thereof and an antibacterial agent comprising the same.

Pyridone carboxylic acid derivatives and salts thereof, process for

Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: ##STR1## wherein A represents a group of the formula, --CH.sub.2 -- or a group of the formula ##STR2## in which R.sup.5 represents a hydrogen atom or an alkyl group, and the bond  represents syn or anti isomer or their mixture; R.sup.3 represents a hydrogen or halogen atom; and R.sup.4 represents a hydrogen atom or an amino group which may be protected or substituted. These cephalosporins have a broad antibacterial spectrum, are stable against .beta.-lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally.

7-(substituted or unsubstituted amino) 3-substituted methyl-.sup.3

This invention relates to a process for industrially producing a 1-substituted aryl-1,4-dihydro-4-oxonaphthyridine derivative and a salt thereof which are useful as an antibacterial agent, and also to intermediates therefor and processes for producing the intermediates.

Nicotinic acid derivatives

Novel substances having carcinostatic and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases lower warm-blooded animals. This disclosure concerns such substances and a process for preparing the same and a carcinostatic agent containing the same.

Novel substances having carcinostatic and immunostimulating activity,

The invention relates to a process for producing a cephalosporin of the formula ##STR1## by reacting the compound ##STR2## with the compound ##STR3## in the presence of boron trifluoride or a complex thereof.

Novel process for producing a cephalosporin

This invention relates to a 7-amino-3-(pyrazinylmethyl)- or (pyridazinylmethyl)-cephalosporins of the formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a carboxyl-protecting group; R.sup.2 represents a group of the formula: ##STR2## in which R.sup.6 represents a hydrogen atom, a C.sub.1-5 alkyl group or a di-C.sub.1-5 alkylamino group; R.sup.13 represents a C.sub.1-5 alkyl group; and R.sup.28 represents an amino group.

7-amino-3-(pyrazinylmethyl) or (pyridazinylmethyl)-cephalosporins

Process for producing 1-substituted aryl-1,4-dihydro-4-oxonaphthyridine

This invention relates to a novel 4-oxo-1,4-dihydronicotinic acid derivative ##STR1## or a salt thereof, wherein R.sup.1 is hydrogen or carboxyl-protecting group;

4-oxo-1,4-dihydronicotinic acid derivatives, salts thereof, and

This invention relates to novel 7-(substituted or unsubstituted amino)-3-substituted methyl-.DELTA..sup.3 -cephem-4-carboxylic acids in which a substituted or unsubstituted 1,2,4-triazolyl or 2-(1,2,3,4-tetrazolyl) group attaches to the exomethylene group at the 3-position of the cephem ring through a carbon-nitrogen bond. These cephalosporins are useful intermediates for producing various novel cephalosporins. Also, this invention concerns a process for producing a compound represented by the formula: ##STR1## which comprises reacting a compound represented by the formula: ##STR2## with an optionally substituted triazole or tetrazole in the presence of an acid or a complex of the acid in an organic solvent at 0.degree. to 80.degree. C.

Novel intermediates of cephalosporins and process for producing

This invention relates to a novel process for producing a 2-(2-aminothiazol-4-yl)glyoxylic acid derivative or a salt thereof which are useful in producing a cephalosporin antibiotic, and to intermediates for said derivative and salt and a process for producing the intermediates.

Novel process for producing 2-(2-aminothiazol-4-yl)glyoxylic acid

This invention relates to a novel aminothiazole intermediate for production of a cephalosporin of antibiotic activity.

Aminothiazole intermediate for a cephalosporin

The invention relates to antibiotic compounds of the formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a carboxyl-protecting group; R.sup.2 represents a group of the formula: ##STR2## R.sup.3 represents a hydrogen atom or an alkoxy group; R.sup.4 represents a hydrogen atom or a halogen atom; R.sup.5 represents a hydrogen atom or a protected or unprotected amino group; A represents a group of the formula, --CH.sub.2 -- or a group of the formula, ##STR3## or a group of the formula, ##STR4## and the bond  means that the compound may be a synisomer or an anti-isomer or a mixture thereof.

Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl)

This invention relates to a novel process for producing a useful cephalosporin which comprises reacting a thiolo ester compound with a 7-aminocephalosporin in the presence of boron trifluoride or a complex compound thereof. This process enables the cephalosporin to be produced with a high purity in a high yield.

Novel process for producing cephalosporins

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Toyama, Japan

Isamu Saikawa