Other

The Calpis Food Industry Co., Ltd.

Calpis Food Industry

Isamu Mitsui

Kenichi Fukunaga

Fumiaki Taguchi

Kinichi Hara

Masaro Hayashi

Kunio Ezawa

Jun Kuranari

Takefumi Iwanami

Kazuo Joko

Tsutomu Watanabe

Motozumi Yamadaki

Yukinori Mori

A substance-conjugated complement component C1q is provided. A substance such as signal emitting substances or cell function regulating substances is conjugated via a sulfur atom to at least one site of the component. The site is not involved in binding immunoglobulins. A marker-labelled complement component C1q is used for measuring a complement-binding antibody, an antigen, a neutralizing antibody or a substance produced internally of and at the surface of a cell or a microorganism by measuring the marker.

Test method involving substance-conjugated complement component C1q

A substance-conjugated complement component Clq is provided. A substance such as signal emitting substances or cell function regulating substances is conjugated via a sulfur atom to at least one site of the component. The site is not involved in binding immunoglobulins. A marker-labelled complement component Clq is used for measuring a complement-binding antibody, an antigen, a neutralizing antibody or a substance produced internally of and at the surface of a cell or a microorganism by measuring the marker.

Substance-conjugated complement component C1q

Novel antimicrobial substance C-3603 was obtained from the culture of Streptococcus mutans C-3603, FERM-P No. 4128, ATCC No. 31383. The novel antimicrobial substance C-3603 shows a high antimicrobial activity against a variety of gram-positive bacteria, particularly cariogenic bacteria in the oral cavity and it is expected for the utilization to prevent oral infectious diseases, particularly dental caries.

Antimicrobial substance C-3603 and process for preparing the same

Growing community of inventors

Yokohama, Japan

Isamu Mitsui