Ishihara Sangyo Kaisha, Ltd.

Isamu Katsuyama

Hiroshi Yoshizawa

Rikuo Nasu

Tadashi Nakamura

Tatsuo Isogai

Takayoshi Ando

Koji Hayashi

Hayato Ariyoshi

Masaru Kimura

Masahiko Sawaki

Taku Shimura

Sho Tokumoto

A method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine, which comprises reacting 3-hydroxy-3-mercaptomethylquinuclidine or a salt thereof and a carbonyl compound in the presence of a catalyst made of at least one member selected from the group consisting of tin halides, oxyacids of phosphorus, phosphorus oxyhalides and organic sulfonic acids, to produce cis-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or a salt thereof.

Method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine

A method for producing a dichloromethylpyridine of the formula (II): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 which are independent of one another, is a hydrogen atom, a halogen atom, an alkoxy group or a phenoxy group which may be substituted, provided that R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are not simultaneously hydrogen atoms, which comprises reacting a trichloromethylpyridine of the formula (I): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, with a reducing agent, wherein:

Method for producing dichloromethylpyridines

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Yokkaichi, Japan

Isamu Katsuyama