Fujifilm Corporation

Japanese National Railways

Hoshi University

Ishikawajima-harima Jukogyo Kabushiki Kaisha

Kyokuto Boeki Kaisha, Ltd.

Swiss Tropical and Public Health Institute

Synstar Japan Co., Ltd.

Schweizerisches Tropen-und Public Health-institut

Isamu Itoh

Masataka Ihara

Yasuyuki Morita

Toshiyuki Ueno

Reto Brun

Nasser Saad Mohamed Ismail

Mei Yang

Jian-Feng Ge

Chika Arai

Saad Mohamed Ismail Nasser

A rhodacyanine derivative represented by the following General Formula (1), wherein, in General Formula (1), R, R, and Reach independently represent an alkyl group which may be substituted; Yand Yeach independently represent a hydrogen atom, a chlorine atom, or a fluorine atom provided that Yand Ydo not represent hydrogen atoms at the same time; and X represents a counter anion. A pharmaceutical composition for treating leishmaniasis including the rhodacyanine derivative and a pharmaceutically acceptable carrier. 

Rhodacyanine derivative and pharmaceutical composition for treating leishmaniasis

Provided is a medicinal composition, in particular, a medicinal composition for treatment and/or prevention which has a high therapeutic effect on infection with a parasitic protozoa and a selective toxicity thereto and exhibits a life-prolonging effect and so on. A medicinal composition which contains as the active ingredient a benzo[a]phenoxazine compound represented by General formula (1) or a salt compound of the same, in particular, an agent for treating and/or preventing infection with a protozoa such as malaria, leishmaniasis, African trypanosomiasis, Chagas disease, toxoplasmosis, lymphatic filariasis, babesiosis or coccidium disease; and a novel compound which is contained therein as the active ingredient.

Medicinal composition containing benzo[a]phenoxazine compound as the active ingredient for prevention or treatment of protozoal disease

A process for excavating and constructing a tunnel, and an excavating device are disclosed. This process is directed to excavating and constructing a tunnel under a railway or a road on a banking or on level land in the direction transverse to the railway or road. In this process, pits are dug on the opposite sides of the railway, and then an excavator digs into the wall of a pit on one side so as to go out of the wall of the other pit through the ground left therebetween. In this respect, a hollow casing unit of a box shape is coupled to the rear end of the excavator equipped with a screw conveyor. As the excavator advances or digs forwards a given distance, another casing unit is in turn coupled to the rear end of the preceding casing unit, and then such a step is repeated, until the excavator goes out of the wall of another pit. In this manner, the excavator further digs into the wall of one pit in the position adjacent to the preceding run of casing units. Then, these runs of casing units are placed around the imaginary contour of a tunnel, thereby forming the outer wall of the tunnel. The sand and soil inside the outer wall of the tunnel is excavated and removed, after which reinforcing steel bars and a mold are placed along the inner surface of the wall of the tunnel. Concrete is then poured into the hollow casing units themselves as well as between the mold and the wall. Thus, the hollow casing units form an integral part of the wall of a tunnel, as an outer wall.

Process for excavating and constructing tunnel and excavating device

A process for excavating and constructing a tunnel, and an excavating device are disclosed. This process is directed to excavating and constructing a tunnel under a railway or a road on a bank or on level land in the direction transverse to the railway or road. In this process, pits are dug on the opposite sides of the railway, and then an excavator digs into the wall of a pit on one side so as to go out of the wall of the other pit through the ground left therebetween. In this respect, a hollow casing unit of a box shape is coupled to the rear end of the excavator equipped with a screw conveyor. As the excavator advances or digs forward a given distance, another casing unit is in turn coupled to the rear end of the preceding casing unit, and then such a step is repeated, until the excavator goes out of the wall of another pit. In this manner, the excavator further digs into the wall of one pit in the position adjacent to the preceding run of casing units. Then, these runs of casing units are placed around the imaginary contour of a tunnel, thereby forming the outer wall of the tunnel. The sand and soil inside the outer wall of the tunnel are excavated and removed, after which reinforcing steel bars and a mold are placed along the inner surface of the wall of the tunnel. Concrete is then poured into the hollow casing units themselves as well as between the mold and the wall. Thus, the hollow casing units form an integral part of the wall of a tunnel, as an outer wall.

Growing community of inventors

Tokyo, Japan

Isamu Itoh