Kyowa Hakko Kogyo Co., Ltd.

Isami Takahashi

Hirofumi Nakano

Tatsuya Tamaoki

Yutaka Saitoh

Makoto Morimoto

Katsuhiko Ando

Isao Kawamoto

Fusao Tomita

Toru Yasuzawa

Mayumi Yoshida

Kozo Asano

Hiroyuki Nagata

Hiroshi Sano

Yutaka Kanda

Tsutomu Akama

Shiro Akinaga

Eiji Kobayashi

Kenichi Mochida

Takao Iida

Keiichi Takahashi

Shun-ichi Ikeda

Atsuhiro Hasegawa

Harumi Ue

Yoshinori Yamashita

Hiromitsu Saito

Tadashi Ashizawa

Keiko Ochiai

Katsushige Gomi

Tamio Mizukami

Mitsunobu Hara

Tsutomu Agatsuma

Kazuhito Akasaka

Kazuhisa Fujimoto

Toshiaki Iwazaki

Yumiko Aotani

Hisayo Nomoto

Michio Ichimura

Kozo Asasno

Teruo Kishi

LK6-A derivatives

Pyrrolo &lsqb;4,3,2-de&rsqb; quinoline derivatives

The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; (1) when X represents halogen, Y represents an oxygen atom or R.sup.4 --O--N (wherein R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl); and R.sup.3 represents hydrogen, alkanoyl, alkenoyl or the like; and (2) when X and R.sup.3 are combined with each other to represent a single bond; Y represents R.sup.4B --O--N (wherein R.sup.4B has the same meaning as R.sup.4). The radicicol derivatives of the present invention demonstrate tyrosine kinase inhibition activity and pharmacological activities such as antitumor, antimicrobial or immunosuppression effects.

Radicicol derivatives

The present invention relates to compound LK6-A represented by the formula: ##STR1## which has immunosuppressive activity, and pharmaceutically acceptable salts thereof.

Compound LK6-A

Disclosed is UCA1064-B, a compound represented by formula (I): ##STR1## and having an antibacterial, antifungal and anti-tumor activity. UCA1064-B is produced by culturing a microorganism belonging to the genus Wallemia.

Compound UCA1064-B

A UCN-1028D derivative represented by the formula: ##STR1## has protein kinase C inhibitory activity and is expected to be used as an active ingredient in anti-tumor agents, etc.

UCN-1028D derivatives

A novel fermentation product, DC113, represented by the formula ##STR1## which has antimicrobial and antitumor activities.

Novel substance DC 113 and production thereof

A novel compound, DC-107, is produced by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.

Compound DC-107 produced by Streptomyces sp.

UCN-1028A and UCN-1028C having an anti-tumor activity and a protein kinase C inhibitory activity are produced by culturing a microorganism belonging to the genus Cladosporium.

UCN-1028A and UCN-1028C and process for the production thereof

UCN-01 having an anti-tumor activity and an anti-bacterial activity is produced by culturing a microorganism belonging to the genus Streptomyces.

UCN-01 and process for production thereof

The present invention relates to DC-88A and DC-89A1 and their production. These compounds are obtained by fermentation of microorganisms belonging to the genus Streptomyces. These compounds have antibacterial and anti-tumor activities and are useful as medicaments.

Pyrindamycins A and B and duocarmycin A antibiotics derived from certain

Antibiotic compounds DC-92B and DC-92D

Growing community of inventors

Machida, Japan

Isami Takahashi