Commissariat a L'energie Atomique Et Aux Energies Alternatives

Commissariat a L'energie Atomique

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Other

The Joseph Fourier University of Grenoble

Sorbonne Université

Université Joseph Fourier

Isabelle Texier-Nogues

Aude Bernardin

Mathieu Goutayer

Guillaume Delapierre

Fabrice Navarro Y Garcia

Jean-Luc Coll

Regis Barattin

Emilie Heinrich

Véronique Robert

Jerome Bibette

Jérôme Bibette

Philippe Peltie

Bertrand Tavitian

Anabela Da Silva

David Bonnaffe

Antoine Hoang

Pascal Dumy

Patrice Marche

Anne Imberty

Didier Boturyn

Xavier Gidrol

David Ratel

Véronique Mourier

Séverine Vignoud

Thomas Courant

Eric Sulpice

Jonathan Bruniaux

François Durrat

Dorothée Jary

Thomas Delmas

Rolande Blanc

Jacques Fattaccioli

Toufic Daou

Marie Favrot

Jean-Sébastien Thomann

Anne-Claude Couffin

Raphaël Boisgard

Juliette Merian

Régis Barattin

Veronique Mourier-Robert

Dominique Lauro

Christophe Gaude

Audrey Le Naour

Véronique Mourier-Robert

The present invention relates to a therapeutic agent formulation in the form of a nano-emulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises further to the therapeutic agent, at least one amphiphilic lipid and at least one solubilizing lipid, and in which the aqueous phase comprises at least one polyalkoxylated cosurfactant. The invention also relates to a preparation method and use of this formulation.

Encapsulation of lipophilic or amphiphilic therapeutic agents in nano-emulsion

The present invention relates to an immunogenic composition comprising a continuous aqueous phase and a dispersed phase as droplets and comprising:

Immunogenic composition in emulsion form

The present invention relates to a formulation of a therapeutic or diagnostic agent in the form of a nano-emulsion, to its preparation method and to the use of this formulation for treating or diagnosing hormone-dependent cancers or cancers of organs synthesizing steroidal hormones.

Formulas for diagnosing and treating hormone-dependent cancers and cancers of the organs responsible for steroid hormone synthesis

A material including a continuous aqueous phase and a dispersed phase in the form of droplets containing an amphiphilic lipid and a surfactant having the following formula (I):(L-X&#x2014;H&#x2014;Y)-G-(Y&#x2014;H&#x2014;X-L)&#x2003;&#x2003;(I),wherein:

Material, method for preparing same, and uses thereof

The invention concerns the field of molecular probe architecture for in vivo imaging. More particularly, the invention concerns molecular constructs providing an imaging function activable in intracellular environment. The inventive fluorescence probes enable in particular images of certain targeted tissues to be formed, while maintaining a low background noise level and, preferably, while obtaining at the targeted tissue, an imaging signal increasing in time.

Target vector with activable imaging function

The present invention relates to a formulation of indocyanine green in the form of a nanoemulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises indocyanine green, at least one amphiphilic lipid and at least one solubilizing lipid. It relates also to a process for the preparation and to the use of the formulation.

Fluorescent emulsion of indocyanine green

A nanocrystal formulation in the form of a nano-emulsion includes a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase has at least one amphiphilic lipid and at least one solubilising lipid, and in which the aqueous phase has a cosurfactant. The invention also relates to a method for the production of the formulation as well as uses within the fields of medical imaging, thermotherapy or phototherapy.

Nanocrystal nano-emulsion

The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.

Fluorescent emulsions for optical imaging

The invention relates to the use of disubstituted alkynes for the functionalisation of the surface of a substrate consisting of a semi-conductor material, with molecules of interest. According to the invention, a compound of formula A-(E1)-F1 is used, wherein A is a linear or cyclic disubstituted alkyne, E1 is an alkyl chain and n2 is 0 or 1, and F1 is a reactive group that can react with the reactive group F2 of a compound of formula F2-(E2)-X wherein E2 is an alkyl chain and X is a group having properties of interest. The invention is especially applicable to the field of molecular biology or biotechnology.

Method for surface functionalization by disubstituted alkynes

The present invention aims to provide a method of use for surface-modifying a semiconductor nanocrystal comprising at least the steps consisting in having a semiconductor nanocrystal, the organic coating layer of which is provided, at the outer surface of the nanocrystal, with at least one reactive group G1 that reacts according to a cycloaddition reaction of click chemistry type; and bringing said nanocrystal together with an adjoining material provided at the surface with at least one G2 group complementary to the G1 group with respect to said click chemistry reaction, under conditions favorable to the interaction of said G1 and G2 groups, characterized in that said G1 and G2 groups are respectively an azide and a strained cycloalkynyl radical, or vice versa.

Semiconductor nanocrystals

The invention relates to compounds comprising a cycloalkyne or heterocycloalkyne group and a redox group. Said compounds are of general formula (I) wherein Z is a cycloalkyne or heterocycloalkyne with at least 8 links, optionally substituted by a halogen atom or a linear or branched C1 to C5 alkyl, A is an organic structure having oxidation-reduction properties, and B is an organic link between the cycloalkyne or heterocycloalkyne cycle and the organic structure A. The invention is especially applicable to the field of molecular electronics.

Bifunctional molecules comprising a cycloalkyne or heterocycloalkyne group and a redox group

The invention relates to a silane compound including a cycloalkyne functionality, to a method for functionalising a solid substrate, and to the solid substrate thus produced. The silane compound of the invention corresponds to the formula X-E-A-Z where X is a silyl group, E is an organic spacer group, A is a single bond or a &#x2014;CONH&#x2014;, &#x2014;NHCO&#x2014;, &#x2014;OCHCONH&#x2014;, &#x2014;NHCOCHO&#x2014;, &#x2014;O&#x2014; or &#x2014;S&#x2014; group, and Z is a cycloalkyne or heterocycloalkyne with at least 8 members. The invention is particularly suitable for use in the field of medicine.

Silane compounds having a cyclic carbon chain including an alkyne function for functionalizing solid substrates and immobilizing biological molecules on said substrates

The present invention is targeted at a novel coupling method of 1,3-dipolar cycloaddition type which is of particular use for the functionalization of biological molecules, such as, for example, proteins, enzymes or nucleic acids, insofar as it can be carried out in an aqueous medium and at ambient temperature.

Process for the functionalization of biological molecules

A fluorescent enzymatic substrate including a backbone saccharide nature having at least one saccharide unit. The saccharide unit includes a fluorophore Fand an inhibitor Iof the fluorescence of F. The fluorophore Fand the inhibitor I, either directly or by the spacer arms Band B, respectively, when at least one Band Bis present, are grafted on the same saccharide unit of the backbone saccharide. One of th groups is Fand Igrafted in the anomeric position 1 of the saccharide unit.

Saccharide fluorescent substrates, preparation method and uses thereof

The present invention relates to fluorescent enzymatic substrates of saccharidic nature having a self-cleavable spacer arm functionalized by a fluorophore F and by at least one inhibitor of the fluorescence of F, to the use thereof for preparation of a diagnostic reagent for functional imaging in vivo, and to the diagnostic reagent for functional imaging containing at least one such enzymatic substrate.

Saccharidic fluorescent substrates, their process of preparation and their use

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Grenoble, France

Isabelle Texier-Nogues