Coletica

Basf Beauty Care Solutions France S.a.s.

Centre National De La Recherche Scientifique

Universite Claude Bernard – Lyon1

Université Claude Bernard Lyon I

Isabelle Orly

Eric Perrier

Marie-Christine Levy

Alain Roger Huc

Valerie Andre

Delphine Rival

Corinne Reymermier

Florence Edwards-Levy

Pascal Sommer

Odile Damour

Charbel Bouez

Claudine Gleyzal

Valérie Andre

Sebastien Bonnet

Colette Dezutter

The invention relates to substances which are capable of protecting FGF-2, to a composition for preventing or controlling degradation of FGF-2, and a method of protecting FGF-2 in the skin from degradation. In particular, the invention relates to an extract ofor ambrette, a rebokza extract, a gougizi berry extract, a banha extract, aextract, a mustard flour extract, a wooyin extract, a barley extract, and/or a sesame extract, in amounts effective to protect FGF-2 from its degradation. Further, the present invention allows the extracellular matrix to be restructured, particularly at the dermis, which is useful, for example, for controlling aging.

Use of substances to protect FGF-2 or FGF-beta growth factor

The disclosed substance restores normal co-expression and interaction between the LOX and NRAGE proteins. Particularly, an effective amount of the substance that modulates the expression and/or activity of LOX of SEQ ID NO: 1 and/or that modulates the expression and/or activity of NRAGE of SEQ ID NO: 2, may be used for the manufacture of a composition for modulating the interaction between the LOX and NRAGE proteins to regulate the balance between the cellular phenomena of proliferation, differentiation and apoptosis, particularly in cases where the balance between these phenomena is disturbed, and especially in cases where the interaction between LOX and NRAGE is absent or altered. The invention makes it possible especially to treat and/or prevent skin ageing, lichen planus, graft-versus-host reaction (GVH), eczema, psoriasis and a cancer, particularly an epithelial cancer and more particularly a cutaneous epithelial cancer of basocellular or spinocellular type.

Substance for restoring normal co-expression and interaction between the LOX and NRAGE proteins

Method for fabricating microparticles in emulsion by modification of the

A collagen-based composition including microcapsules of atelocollagen or of a mixture of atelocollagen and a polysaccharide, particularly glycosaminoglycan, suspended in a viscous biocompatible carrier solution. Together, the microcapsules and the viscous carrier solution preferably have a viscosity such that the composition may be injected, in particular as a continuous thread from a needle. Said composition is readily injectable and may be used as a soft or bony tissues filling material for, or as a system for the controlled delivery and release of biologically, cosmetically or pharmaceutically active substances.

Injectable compositions containing collagen microcapsules

Particles prepared by transacylation reaction between an esterified

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Lyons, France

Isabelle Orly