Syngenta Participations Ag

Devgen Nv

Isabelle Maillet

Yann Naudet

Pascale Feldmann

Myriam Beghyn

Lies Degrave

Annelies Philips

Lien De Schrijver

Jeffrey David Fowler

Kevin V Donohue

Nema Devi Jhurry

Marta Omedes Pujol

Kevin L Donohue

Disclosed are double stranded RNA (dsRNA) molecules that are toxic to insect pests. In particular, interfering RNA molecules capable of modulating expression of a pest insect target gene and that are toxic to the insect pest are provided. Further, methods of making and using the interfering RNA, for example as the active ingredient in an insecticidal composition or in a transgenic plant, to confer protection from insect damage are disclosed.

Control of plant pests using RNA molecules

Disclosed are double stranded RNA molecules that are toxic to coleopteran insects. In particular, interfering RNA molecules capable of interfering with pest target genes and that are toxic to the target pest are provided. Further, methods of making and using the interfering RNA, for example in transgenic plants or as the active ingredient in a composition, to confer protection from insect damage are disclosed.

Control of coleopteran pests using RNA molecules

Methods of substantially retaining or otherwise preserving the biological activity of a dsRNA, present in a cell, to post-transcriptionally silence the expression of a gene in a target organism, comprising the step of adding to the cell composition a compound having the function of a protein&#x2014;or amine&#x2014;cross linking agent and/or an acid, and compositions comprising the cells comprising dsRNA, and protein cross linking agents and/or acids, as well as the use of the cross linking agents and/or acids in the method.

Methods of preserving the biological activity of ribonucleic acids

Growing community of inventors

Ghent, Belgium

Isabelle Maillet