Pierre Fabre Medicament

Isabelle Leroy

Elisabeth Dupont-Passelaigue

Didier Junquero

Karine Valeille

Yves Rival

Samuel Mialhe

André Delhon

Jean-François Patoiseau

Elisabeth Dupont-passelaigue

The present invention relates to compounds having general formula I characterized in that  

Nitrogen heterocycle derivatives, preparation thereof and application thereof in human therapeutics

The present invention relates to derivatives of general formula I wherein: &#x2014;W represents nitrogen, &#x2014;Rrepresents: &#x2022;a hydrogen or a linear or branched C-Calkyl radical or, &#x2022;a C-Calkyl radical substituted with groups such as trifluoromethyl, nitrile, hydroxy, C-Calcoxy, C-Calkoxyalkoxy, indolyl, thiophenyl, oxothiophenyl, C-CN-alkylcarbamoyl groups or, &#x2022;a phenyl or pyridyl or naphthyl, or thiophenyl group optionally substituted with one or more groups such as halogen atoms, nitro, nitrile, trifluoromethyl, vinyl, methylsulfanyl, linear branched C-Calkyl, linear or branched C-Calkoxy groups, &#x2022;a C2-oxocycloalkyl radical&#x2014;Rrepresents a methyl or heptyl, -m, n are equal to 1, &#x2014;V represents CH, &#x2014;X&#x2014;Y represents &#x2014;N&#x2014; (C&#x2550;O)&#x2014;, &#x2014;CH&#x2014;O&#x2014;, &#x2014;Z represents a phenyl group substituted with one or more trifluoromethyl groups, halogen atoms or linear C-Calkyl groups. 

Derivatives of triazines and uracils, their preparation and their application in human therapeutics

The invention relates to 3,5-dioxo-(2H,4H)-1,2,4-triazine compounds of formula I in which the variables are defined herein, as well as additive salts with pharmaceutically acceptable bases and the various enantiomers of compounds having asymmetrical carbons, as well as their mixtures in all proportions, including racemic mixtures in particular.

1,2,4-triazine derivatives, preparation and use thereof in human therapy

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Saix, France

Isabelle Leroy