Enobia Pharma Inc.

Alexion Pharmaceuticals, Inc.

Clementia Pharmaceuticals Inc.

Alexion Pharma Holding

Isabelle Lemire

Philippe Crine

Guy Boileau

Thomas P Loisel

Denis Gravel

Elaref S Ratemi

Mostafa Hatam

Donna Roy Grogan

Clarissa Desjardins

Pierre Leonard

Robert Heft

Michael Harvey

Hal Landy

A bone delivery conjugate having a structure selected from the group consisting of: A) X-D-Y-protein-Z; and B) Z-protein-Y-D-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dis a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.

Bone delivery conjugates and method of using same to target proteins to bone

The invention features methods for inhibiting the formation, reducing the size, and slowing the growth of an osteochondroma in a subject with multiple osteochondroma (MO) by administering to the subject palovarotene (also known as R667), or a pharmaceutically acceptable salt thereof. The methods described herein can also ameliorate complications associated with osteochondroma formation and growth in a subject with MO.

Methods for treating multiple osteochondroma (MO)

The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: 

Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX

The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula:  useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.

Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex

Growing community of inventors

Montreal, Canada

Isabelle Lemire