Centre National De La Recherche Scientifique

Bio-rad Innovations

Bio-rad Europe Gmbh

Bio-rad Pasteur

Universitè De Montpellier

Electrophoretics Limited

Université Montpellier I

Isabelle Karine Giuliani

Francois Yves Rieunier

Sylvie Villard-Saussine

François Yves Rieunier

Catherine Larue

Johann Guegan

Bernard Pau

Catherine Christiane Marie Larue

Sylvie Marie-France Trinquier

Isabelle Nathalie Garric

François Rieunier

The present invention relates to a polypeptide carrying a human BNP(1-32) epitope according to Formula (I): a-R-X-FGRKMDR-X-R-aas well as ligands specific of the FGRKMDR epitope.

BNP (1-32) epitope and antibodies directed against said epitope

The present invention relates to a polypeptide carrying a human BNP(1-32) epitope according to Formula (I): a-R&#x2014;X&#x2014;FGRKMDR&#x2014;X&#x2014;R-aas well as ligands specific of the FGRKMDR epitope.

The present invention relates to a polypeptide carrying a human BNP(I-32) epitope according to Formula (I): a-R-X-FGRKMDR-X-R-aas well as ligands specific of the FGRKMDR epitope.

BNP(1-32) epitope and antibodies directed against said epitope

The present invention relates to a method for the in vitro diagnosis of stroke and transient ischemic attack (TIA) in an individual, comprising the following steps:

Method for the in vitro diagnosis of stroke

A method for the in vitro diagnosis of stroke and transient ischemic attack (TIA) in an individual, including the following steps: (a) measuring the level of proBNP(1-108), or of fragments of proBNP(1-108) including a RAPRSP sequence (SEQ ID NO: 1), in a biological sample of the individual; (b) measuring the level of nucleoside diphosphate kinase A (NDKA) in a biological sample of the individual; (c) comparing the level of proBNP(1-108), or of fragments of proBNP(1-108), and the level of NDKA, with one or several cut-off values; and (d) determining therefrom whether a stroke or a TIA has occurred in the individual.

The invention concerns the use of at least a synthetic compound comprising: a carrier molecule having at least a hydrocarbon chain comprising at least 10, advantageously at least 12, preferably at least 14 and not more than 300, advantageously not more than 100, preferably not more than 50, selected'among C, N, O, S, P and Si, and comprising at least two reactive functions, or capable of reacting, for grafting lateral arms on said chain, and at least two different epitopes carried by said lateral arms grafted on said carrier molecule, as standard or control for immunoassay of said biological molecules, in particular of polypeptides or proteins.

Use of stabilised synthetic compounds in immunoassay

The invention relates to an in vitro diagnosis of heart failure. More specifically, the invention relates to specific antibodies of a peptide domain which is situated on either side of hinge region R76S77 of proBNP(1-108). In particular, the invention relates to a method of obtaining the aforementioned antibodies and to the use thereof in detecting blood proBNP(1-108) with the exception of BNP(1-76) and BNP(77-108). The invention also relates to a method of detecting blood proBNP(1-108), reagents and a kit for same.

Growing community of inventors

Montpellier, France

Isabelle Karine Giuliani