Aventis Pharma S.a.

Isabelle Depaty

Francois Clerc

Chantal Carrez

Odile Angouillant-Boniface

Stéphanie Deprets

Francois Hamy

Manfred Roesner

The present invention discloses and claims benzimidazole compounds of formula (I):in which A is aryl or heteroaryl; Ris selected from optionally substituted alkyl, alkoxy, aryl or heteroaryl, NH-lower alkyl or NH-cycloalkyl, or halogen, NH; 1-imidazolyl or SOMe; Ris selected from optionally substituted &#x2014;CO-alkyl, &#x2014;CO-cycloalkyl, &#x2014;CO-aralkyl, &#x2014;CO-aryl, &#x2014;CO-alkoxy, aryl or aralkyl, or &#x2014;CO-amino, CO&#x2014;NHRor CO&#x2014;RRwherein Rand Rare selecteded independently from hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, fluoroalkyl, alkynyl, heteroalkyl, alkylheteroalkyl, aryl, aralkyl or together form an alkylene chain optionally containing one to 4 heteroatoms; a pharmaceutically acceptable salt or a prodrug thereof; the use of compounds of formula (I) for the treatment of cancer, and pharmaceutical compositions comprising a compound of formula (I) and one or more pharmaceutically acceptable adjuvants or diluents.

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Paris, France

Isabelle Depaty