Institut National De La Sante Et De La Recherche Medicale

Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Institute Pasteur De Lille

Isabelle Bourgault-Villada

Jean-Gérard Guillet

Bernard Maillere

Hélène Gras-Masse

André Tartar

Marc Bossus

Guy Lippens

Sandra Pouvelle-Moratille

Jean-Michel Wieruszeski

The invention concerns a mixture of peptides derived from the E6 and/or E7 proteins of a papillomavirus involved in cervix of uterus cancer, such as HPV16, HPV18, HPV30, HPV31, HPV32, HPV33, HPV34, HPV35, HPV39, HPV40, HPV42, HPV43, HPV44, HPV45, HPV51, HPV52, HPV56, HPV57, and HPV58, for example, as well as its uses as medicine (in immunogenic compositions, capable of stimulating the production of anti-HPV T CD4+ lymphocytes in vivo and hence useful for vaccination against uterine of uterus cancer and in other cancers) or as diagnostic reagent of HPV-specific T lymphocytes, in particular for assessing the immune condition of patients. The invention also concerns a mixture of peptides derived from E6 and/or E7 proteins of a papillomavirus involved in benign skin lesions (for example warts), such as HPV10, HPV3 or HPV4 and its uses as medicine.

Mixture of peptides derived from E6 and/or E7 papillomavirus proteins and uses thereof

The invention concerns mixed micelles or micro-aggregates for inducing an immune response containing at least a first lipopeptide comprising a CTL epitope and at least a first lipid motif; and a second lipopeptide comprising at least an auxiliary T epitope and at least a lipid motif, whereof the type can be different from the first lipopeptide motif. Said micelles can be used as medicines and vaccines.

Mixed lipopeptide micelles for inducing an immune response

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Paris, France

Isabelle Bourgault-Villada