Aziende Chimiche Riunite Angelini Francesco A.c.r.a.f. S.p.a.

Isabella Coletta

Guido Furlotti

Nicola Cazzolla

Giorgina Mangano

Maria Alessandra Alisi

Caterina Maugeri

Patrizia Dragone

Barbara Garofalo

Angelo Guglielmotti

Lorenzo Polenzani

Beatrice Garrone

Vincenzo Russo

Rosella Ombrato

The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment or prevention of disturbances associated with the production of prostaglandin E(PGE), for instance inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis.

3-aminocarbazole compound, pharmaceutical composition containing it and preparation method therefor

An (aza)indole derivative substituted in position 5, of formula (I) in which X, Y, Z, G1, G2, G3, R1, W, and R2 have the meanings given in the description, a pharmaceutical composition comprising it, and also intermediate compounds and a preparation process therefor. 

(Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor

Use of a benzoyl derivative of 3-aminocarbazole to produce a drug for the preventive or therapeutic treatment of a disorder selected form the group comprising inflammatory processes, pain, fever, tumors, Alzheimer's disease and atherosclerosis. Method for the preventive or therapeutic treatment of a disorder selected from the group comprising inflammatory processes, pain, fever, tumors, Alzheimer's disease and atherosclerosis in which a therapeutically effective quantity of a benzoyl derivative of 3-aminocarbazole according to the invention is administered to an individual.

[object Object]

A method for treating an inflammatory process selected from the group consisting of oedema, erythema, articular inflammation, rheumatoid arthritis, arthrosis, a colorectal tumor, a pulmonary carcinoma, an adenocarcinoma, and combinations thereof, in a person in need thereof, the method comprising administering to the person in need thereof, in an amount sufficient to treat the inflammatory process, a 3-aminocarbazole or a salt thereof.

3-aminocarbazole compounds, pharmaceutical composition containing the same and method for the preparation thereof

A 2-arylindole compound substituted in position 5, of formula (I): in which X, Y, Z, W, A, R and R' have the meanings given in the description, a pharmaceutical composition comprising it, and also intermediate compounds and a preparation process therefor. 

2-arylindole derivatives as nPGES-1 inhibitors

A compound of formula (I), in which R1, R2, R3, R4, R5, R6, X and Y have the meanings indicated in the description, and the pharmaceutically acceptable salts thereof. A pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof. A method for preparing the abovementioned compound of formula (I) and the pharmaceutically acceptable salts thereof. 

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Rome, Italy

Isabella Coletta