Sanofi-A Ventis Deutschland Gmbh

Bionet Pharma Gmbh

Sanofi

Isabell Schoettle

Christiane Fuerst

Walter Kamm

Julia Schnieders

Paul Habermann

Ulrich Werner

Peter Boderke

Werner Mueller

Verena Siefke-Henzler

Petra Loos

Bernd Janocha

Annika Hagendorf

Gerrit Hauck

Joachim Saas

Katrin Tertsch

Reinhard Becker

Annke Hahn

Judith Stommes

Ursula Stillger

Eckart Bartnik

Volker Jeske

Annke Frick

Werner Müller

Werner Muller

The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further relates to a composition comprising CD-RAP and at least one positively charged amino acid and a buffer, pharmaceuticals comprising said composition, their use in methods of treating and/or preventing cartilage disease or injury in patients suffering from aggrecan degradation, and/or increased influx of water into the cartilage, and/or decreased CD-RAP expression, as well as methods of producing said composition and methods of storing CD-RAP in said composition. The present invention further relates to a composition comprising liposomes comprising encapsulated CD-RAP or a variant thereof, its use in methods of treating joint disease or injury, and methods of producing such liposomal composition as well as storing CD-RAP therein.

Expression and folding in the manufacturing process of CD-RAP by using a CD-RAP precursor protein

A liquid composition comprising a GLP-1 agonist or/and a pharmacologically tolerable salt thereof, an insulin or/and a pharmacologically tolerable salt thereof, and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin where appropriate.

Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine

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Frankfurt am Main, Germany

Isabell Schoettle