Novartis Vaccines & Diagnostics, Gmbh

Xoma Technology Ltd.

Isabel Zaror

Li Long

Mohammad Luqman

Asha Yabannavar

Sang Hoon Lee

Bao-lu Chen

Sharon Lea Aukerman

Deborah Hurst

Xiaofeng Lu

Bao-Lu Chen

Mohammed Luqman

Daniel E Lopes De Menezes

Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.

Antagonist anti-CD40 monoclonal antibodies and methods for their use

Antagonist anti-CD40 antibodies

Growing community of inventors

El Cerrito, CA, United States of America

Isabel Zaror