Eli Lilly and Company

Ligand Pharmaceuticals, Inc.

Isabel Rojo

Alan M Warshawsky

Michael J Rodriguez

Robert J Ardecky

Jolie Anne Bastian

James Robert Henry

Deqi Guo

Richard Duane Johnston

Dawn Alisa Brooks

Almudena Rubio

Gaiying Zhao

David Anthony Barda

Carlos Lamas-Peteira

Jason Eric Lamar

Mohammad Sadegh Zia-Ebrahimi

Kelly Wayne Furness

Lourdes Prieto

Jose Alfredo Martin

Santiago Carballares Martin

Rafael Ferritto Crespo

Chong Si

Tao Liu

Pablo Garcia Losada

Wenceslao Lumeras Amador

Sonia Maria Gutierrez Sanfeliciano

Victoriano Molero Florez

Maria Lourdes Prieto Vallejo

Chahrzad Montrose-Rafezadeh

Anne-Reifel Miller

Maria Rosario Gonzales Garcia

Alicia Torrado

Maria Martin-Ortega Finger

Matthew Patrick Baumgartner

Mario Barberis

The present invention provides compounds of the formula:

KRas inhibitors

Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, &#x2014;CH&#x2014; or &#x2014;CHCH&#x2014;; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to Rand W, Ris (CH)&#x2014;CH(OR)&#x2014;(CH)E, &#x2014;(CH)&#x2550;C(OR)&#x2014;(CH)E, &#x2014;(CH)&#x2014;CH(Y)&#x2014;(CH)E or (CH)&#x2550;C(Y)&#x2014;(CH)E; wherein E is COOR, C&#x2013;Calkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C&#x2013;Calkyl, haloalkyl and aryl-C-4-alkyl; Ris H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, &#x2014;COR, &#x2014;COOR, &#x2014;CONRR, &#x2014;C(S)R, &#x2014;C(S)ORor C(S)NRR, Ris H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O&#x2014;, CH&#x2014;, &#x2014;CHCH&#x2014; or CH&#x2550;CH&#x2014; and is bonded to a carbon atom in Phenyl Ring A that is ortho to R. R&#x2013;Rare independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2 

Modulators of peroxisome proliferator activated receptors

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Madrid, Spain

Isabel Rojo