Agency for Science, Technology and Research

Ethicon, Gmbh

Depuy Synthes Products, Inc.

Ethicon Endo-surgery, Inc.

Endo-surgery, Inc.

Isabel Rodriguez

Kevin L Cooper

Hong Yee Low

Sriram Natarajan

Chee Tiong Lim

Murty Narayan Vyakarnam

Audrey Yoke Yee Ho

Noha Elmouelhi

Emma Kim Luong-Van

Joseph J Hammer

Christina Yuan Ling Tan

Kambiz Ansari

Jarrett Dumond

Shilin Chen

Yee Chong Loke

Fung Ling Yap

Eva Maria Perez-prat Vinuesa

Sharon Roslyn Oh

Alberto Martinez Becares

An implant having an adhesive structure comprising a planar surface having two sides and rectangular cuboid-based protrusions having pyramidal tips extending from at least one of said sides, optionally having a porous basic supporting structure, and methods of making and using such implants.

Adhesive structure with tissue piercing protrusions on its surface

The present disclosure relates to a method of forming a metallic layer having pores extending therethrough, the method comprising the steps of: (a) contacting a cathode substrate with an electrolyte solution comprising at least one cation; reducing the cation to deposit the metallic layer on a surface of the cathode substrate; and (c) generating a plurality of non-conductive regions on the cathode substrate surface during reducing step (b); wherein the deposition of the metallic layer is substantially prevented on the non-conductive regions on the cathode substrate surface to thereby form pores extending through the deposited metallic layer. The present disclosure further provides a metallic porous membrane fabricated by the disclosed process.

Porous metallic membrane

A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 &#x3bc;m to about 3 &#x3bc;m, and heights from about 2 &#x3bc;m to about 20 &#x3bc;m from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.

Super-hydrophilic structures

A laminate and process of making the laminate is disclosed comprising: a surgical mesh having first and second surfaces; and an adhesive structure having adhesive and non-adhesive surfaces, wherein the non-adhesive surface of the adhesive structure is laminated to at least one of said first and second surfaces of said surgical mesh, and the adhesive surface of said adhesive structure has protrusions extending therefrom comprising a resin having a Young's modulus of greater than 17 MPa, which protrusions are of sufficiently low diameter to promote adhesion by increasing physical attractive forces between the adhesive structure and a target surface, as measured by shear adhesion.

Adhesive structure with stiff protrusions on adhesive surface

For forming a nickel mold, a metal and a corresponding etchant are selected such that the etchant selectively etches the metal over nickel. The metal is sputtered onto a surface of a template having nano-structures to form a sacrificial layer covering the nano-structures. Nickel is electroplated onto the sacrificial layer to form a nickel mold, but leaving a portion of the sacrificial layer exposed. The sacrificial layer is contacted with the etchant through the exposed portion of the sacrificial layer to etch away the sacrificial layer until the nickel mold is separated from the template. Subsequently, the nickel mold may be replicated or scaled-up to produce a replicate mold by electroplating, where the replicate mold has nano-structures that match the nano-structures on the template. The metal may be copper.

Systems and processes for forming molds such as nickel molds

A blood clotting substrate and device which has a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film.

Blood clotting substrate and medical device

Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 &#x3bc;m to about 400 &#x3bc;m, heights in the range from about 2.5 &#x3bc;m and about 500 &#x3bc;m, and said pillars have diameters in the range from about 20 nm to about 5 &#x3bc;m and aspect ratios of from about 2 to about 50, and methods of making and using them.

Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them

Growing community of inventors

Singapore, Singapore

Isabel Rodriguez