Harvard College

Massachusetts Institute of Technology

Children's Medical Center Corporation

Ipsen Pharma S.a.s.

Isaac M Chiu

Bradley Lether Pentelute

R John Collier

Sai Man Liu

Felipe Almeida De Pinho Ribeiro

Pankaj Baral

Nicole J Yang

Michael Wessels

Buket Baddal

Shilpa Palan

Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these engineered fusion proteins or compositions containing the engineered fusion proteins. The engineered fusion proteins contain domains derived from protein toxins such as the anthrax toxin, clostridial botulinum family of toxins, disulphide-containing toxins, and AB component type toxins.

Compositions and methods for treatment of pain

Described herein are methods and compositions for treating and/or preventing a microbial infection. Aspects of the invention relate to administering to a subject an agent that inhibits CGRP release and CGRP receptors. In some embodiments of any of the aspects, a subject has been diagnosed with having, or is at risk of having, a microbial infection.

Methods and compositions for treating a microbial infection

Growing community of inventors

Cambridge, MA, United States of America

Isaac M Chiu