Duke University

Isaac B Hilton

Charles A Gersbach

Joshua B Black

David G Ousterout

Pablo Perez-Pinera

Pratiksha I Thakore

Ami M Kabadi

Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.

Compositions and methods for epigenome editing

Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based system related compositions for altering gene expression and genome engineering. Also disclosed herein are compositions and methods of using said compositions for altering gene expression and genome engineering in muscle, such as skeletal muscle and cardiac muscle.

RNA-guided gene editing and gene regulation

Growing community of inventors

Durham, NC, United States of America

Isaac B Hilton