American Cyanamid Company

Irwin B Wood

John A Pankavich

James M Quinlan

Richard B Toothill

Joseph C Dietz

Katsuaki Tadenuma

Osamu Morikawa

Osamu Taniguchi

There are provided non-aqueous pour-on, water-fast formulations effective for the control of internal and external parasitic infections and infestations of homothermic animals such as mammalian quadrupeds. The pour-on formulations of the present invention contain as the active ingredient, a compound selected from the group consisting of LL-F28249&agr;-&lgr;, 23-oxo (keto) and 23-imino derivatives of the compounds collectively defined as LL-F28249, and milbemycin and avermectin molecules.

Pour-on formulations effective for the control of internal and external parasites of homothermic animals

The present invention relates to methods and compositions for the control and prevention of helmintic, arthropod ectoparasitic and acaridal infections, in warm-blooded animals, such as meat-producing animals, and poultry, by administering to said animals a therapeutically or prophylactically-effective amount of new agents designated LL-F28249.alpha., .beta., .gamma., .delta., .epsilon., .xi., .eta., .theta., .iota., .kappa., .lambda., .mu., .upsilon. and .omega., or mixtures thereof. The invention also relates to methods for the control of plant nematode infestations and other insecticidal activities. These novel agents are produced via a controlled conditioned microbiological fermentation using Streptomyces cyaneogriseus ssp. noncyanogenus, designated LL-F28249 and having deposit accession number NRRL 15773.

Method and compositions for helmintic, arthropod ectoparasitic and

A sustained release bolus composition, containing a prophylactically effective amount of a compound selected from LL-F28249.alpha., 23-(O-methyloxime)-LL-F28249.alpha. and derivatives thereof provides a method for protecting ruminant animals for a prolonged period of time against infestation by nematodes, acarids and endoand ectoparasitic insects, and which over time can also eliminate the initial population of parasites present at treatment. The invention also relates to a method for the systemic control of ectoparasitic insect infestations of ruminant animals by orally administering to said animals a sustained release bolus containing an insecticidally effective amount of LL-F28249.alpha., 23-(O-methyloxime) LL-F-28249.alpha. or derivative thereof, which continuously releases into the rumen of the treated animal a systemically effective amount of LL-F28249.alpha., 23-(O-methyloxime)LL-F28249.alpha. or derivative thereof.

Sustained release bolus effective for the prolonged prevention,

The present invention relates to methods and compositions for the control and prevention of helmintic, arthropod ectoparasitic and acaridal infections, in warm-blooded animals, such as meat-producing animals, and poultry, by administering to said animals a therapeutically or prophylactically-effective amount of new agents designated LL-F28249.alpha., .beta., .gamma., .delta., .epsilon., .xi., .eta., .theta., .iota., .kappa., .lambda., .mu., .nu. and .omega., or mixtures thereof. The invention also relates to methods for the control of plant nematode infestations and other insecticidal activities. These novel agents are produced via a controlled conditioned microbiological fermentation using Streptomyces cyaneogriseus ssp. noncyanogenus, designated LL-F28249 and having deposit accession number NRRL 15773.

The present invention relates to methods and compositions for the control and prevention of helmintic, arthropod ectoparasitic and acaridal infections, in warm-blooded animals, such as meat-producing animals, and poultry, by administering to said animals a therapeutically or prophylactically-effective amount of new agents designated LL-F28249.sub..alpha., .beta., .gamma., .delta., .epsilon., .xi., .eta., .theta., .tau., .kappa., .lambda., .mu., .nu., and .sub..omega., or mixtures thereof. The invention also relates to methods for the control of plant nematode infestations and other insecticidal activities. These novel agents are produced via a controlled conditioned microbiological fermentation using Streptomyces cyaneogriseus ssp. noncyanogenus, designated LL-F28249 and having deposit accession number NRRL 15773.

The present invention relates to methods and compositions for the control and prevention of helmintic, arthropod ectoparasitic and acaridal infections, in warm-blooded animals, such as meat-producing animals, and poultry, by administering to said animals a therapeutically or prophylactically-effective amount of new agents designated LL-F28249.alpha., .beta., .gamma., .delta., .epsilon., .zeta., .eta., .theta., .iota. and .omega., or mixtures thereof. The invention also relates to methods for the control of plant nematode infestations. These novel agents are produced via a controlled conditioned microbiological fermentation using Streptomyces sp. LL-F28249, having deposit accession number NRRL 15773.

There is provided a method for controlling nematodes in warm-blooded animals by orally administering thereto a nematocidally effective amount of a new antibiotic or mixture of antibiotics produced in a microbiological fermentation under controlled conditions using a newly discovered strain of Actinomadura yumaense and mutants thereof. There is also provided a method for controlling nematodes in soil by applying to said soil a nematocidally effective amount of the above-mentioned antibiotic or antibiotic mixture.

Controlling nematodes in animals and soil with nematocidal antibiotics

The present invention relates to a novel method for controlling nematodes in plants by applying to the plants, pesticidally-effective amounts of dl or l-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole, acylamino derivatives, or water-soluble acid salts thereof.

Method of controlling plant nematodes

This disclosure describes compositions of matter useful for the treatment and prophylaxis of hemorrhagic colitis in swine and the methods of controlling and preventing hemorrhagic colitis in swine therewith, the active ingredients of said compositions of matter being antibiotic AV290, antibiotic AV290 sulfate, an antibiotic AV290-syntan complex, an antibiotic AV290-alkyl sulfate complex, and/or an antibiotic AV290 alkylated derivative.

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Yardley, PA, United States of America

Irwin B Wood