University of Nebraska

Sorrento Therapeutics, Inc.

Irving H Zucker

Hanjun Wang

Alicia Marie Schiller

Peter Ricci Pellegrino

Ioannis Chatzizisis

Han-Jun Wang

Dong Wang

Thomas Nicholas

Michael Lankhorst

Lie Gao

Juan Hong

Steven Lisco

Compositions and methods for the treatment of peripheral artery disease and cardiopulmonary diseases or disorders are provided. In accordance with the instant invention, methods of inhibiting, treating, and/or preventing peripheral artery disease or symptoms associated therewith are provided. In a particular embodiment, the methods inhibit, treat, and/or prevent claudication associated with peripheral artery disease.

Compositions and methods for the treatment of peripheral artery disease and cardiopulmonary diseases

Technology is described that can be used for continuous measurements of blood pressure and arterial blood flow to automatically derive time-varying estimates of multiple factors pertaining to a patient's vascular system. Such factors can include, but are not limited to, resistive flow, capacitive flow, vascular resistance, and arterial capacitance. Determination of such factors can allow for the meaningful assessment of the control of vascular resistance and capacitance in real time.

Time-varying quantification of capacitive and resistive arterial blood flow

There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient to chemically denervate vanilloid 1 receptor (TRPV1)-expressing CSAR (cardiac sympathetic afferent reflex) afferents. There is further disclosed a method for treating heart failure or hypertension and its related indications selected from the group consisting of increased sympatho-excitation, cardiac hypertrophy, increased left ventricular end diastolic pressure (LVEDP), lung edema, and combinations thereof, comprising administering an effective amount of RTX directly to a tissue site selected from the group consisting of epicardium, a T1-T4 dorsal root ganglion and intrathecally to the T1-T4 region of the spinal column.

Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin

Technology is described that can be used for continuous measurements of blood pressure and arterial blood flow to automatically derive time-varying estimates of multiple factors pertaining to a patients vascular system. Such factors can include, but are not limited to, resistive flow, capacitive flow, vascular resistance, and arterial capacitance. Determination of such factors can allow for the meaningful assessment of the control of vascular resistance and capacitance in real time.

Sympathetic vasomotor identification and quantification systems that provide ways to assess therapies, diseases, and conditions which affect sympathetic innervation and function are described. Because sympathetic vasomotion relies on intact, functional sympathetic nerves, some embodiments of the sympathetic vasomotor identification and quantification systems described herein include a signal processing functionality that establishes sympathetic vasomotor signatures through the collection of arterial blood pressure and blood flow signals.

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Omaha, NE, United States of America

Irving H Zucker