Calera Corporation

University of California

Calimmune, Inc.

Irvin Chen

Miguel Fernandez

Brent Richard Constantz

Martin Devenney

Chris L Camire

Joshua Patterson

Kasra Farsad

Matthew Ginder-Vogel

Patricia Tung Lee

Laurence Clodic

Otto O Yang

Scott G Kitchen

Jerome A Zack

Guillaume Calas

Katharine Geramita

William L Bourcier

Michael Joseph Weiss

Kyle Self

Geoffrey Phillip Symonds

Karin Yaccato

Dong Sung An

Sidney Omelon

Terence C Holland

John Stagnaro

Eric Ha

Justin Ries

Ryan Thatcher

Paulo J M Monteiro

Masakazu Kamata

Peng Lu

Samuel O Morgan

Louis Randall Breton

Treavor Kendall

Keith Hodson

Ayub Ali

Hwee Ng

Chantel Cabrera Tester

Chris Camire

Maureen Boyd

Michelle L Millington

Disclosed herein are methods for selectively expanding cells expressing chimeric antigen receptors and enriching cells expressing chimeric antigen receptors in compositions and methods of treating HIV infection in subjects by administering the expanded and/or enriched cells.

Methods for selectively expanding and enriching cells transduced with chimeric antigen receptors and treating HIV infection

The HIV-specific cytotoxic T lymphocyte (CTL) response is a critical component in controlling HIV replication and is an important part of the ultimate failure to eradicate the virus. Disclosed herein are methods for genetically enhancing the HIV-specific CTL response to allow long-term viral suppression or viral clearance. Human hematopoietic stem cells (HSCs) were genetically modified such that they differentiate into mature CTLs that will kill HIV infected cells. As disclosed herein, the functional effector cells are not human leukocyte antigen (HLA)-restricted. As disclosed herein, stem cells are transduced with non-HLA restricted chimeric antigen receptors (CARs) that allow the recognition of HIV or HIV-infected cells when expressed by a CTL. These CARs are hybrid molecules that contain an extracellular HIV recognition domain and an intracellular TCR-zeta signaling domain. The CTL response may be enhanced through the targeting of T cell inhibitory receptors. The methods and compositions disclosed herein may be used to engineer antiviral immunity and HIV-specific CTL responses in vivo. Also disclosed herein are methods and compositions for the treatment of chronic viral infections such as HIV.

Engineering antiviral T cell immunity through stem cells and chimeric antigen receptors

Provided herein are methods comprising a) treating a slag solid or carbide lime suspension with an ammonium salt in water to produce an aqueous solution comprising calcium salt, ammonium salt, and solids; b) contacting the aqueous solution with carbon dioxide from an industrial process under one or more precipitation conditions to produce a precipitation material comprising calcium carbonate and a supernatant aqueous solution wherein the precipitation material and the supernatant aqueous solution comprise residual ammonium salt; and c) removing and optionally recovering ammonia and/or ammonium salt using one or more steps of (i) recovering a gas exhaust stream comprising ammonia during the treating and/or the contacting step; (ii) recovering the residual ammonium salt from the supernatant aqueous solution; and (iii) removing and optionally recovering the residual ammonium salt from the precipitation material.

Methods and systems for utilizing carbide lime or slag

Provided herein are compositions, methods, and systems for a material containing metastable carbonate and stabilizer. Methods for making the compositions and using the compositions are also provided.

Methods and compositions using calcium carbonate and stabilizer

Provided herein are compositions, methods, and systems for cementitious compositions containing calcium carbonate compositions and aggregate. The compositions find use in a variety of applications, including use in a variety of building materials and building applications.

Concrete compositions and methods

Provided herein are compositions and methods including hydraulic cement, supplementary cementitious material, and/or self-cementing material. Methods for making the compositions and using the compositions are provided.

Methods and compositions using calcium carbonate

Provided herein are systems, methods, and compositions related to mixtures of calcium aluminate cements with compositions comprising carbonate. The compositions comprising carbonates may be formed by sequestering carbon dioxide.

Cement and concrete with calcium aluminates

Provided are compositions, methods and systems including cementitious compositions and reinforcing materials wherein the cementitious composition comprises a metastable component.

Cement and concrete with reinforced material

Formed building materials comprising a sequestered COare provided. The building materials of the invention include a composition comprising a carbonate/bicarbonate component. Additional aspects of the invention include methods of making and using the formed building materials.

Formed building materials

Growing community of inventors

Santa Clara, CA, United States of America

Irvin Chen