Yeda Research and Develpment & Co. Ltd

Other

Alma Bio Therapeutics

Universitatsklinikum Hamburg-eppendorf

Stem Cell Medicine Ltd.

The Brigham and Women's Hospital, Inc.

Ben-gurion University of the Negev Research and Development Authority

Mor Research Applications Ltd.

The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center

The Weizmann Institute of Science

B.g. Negev Technologies and Applications Ltd.

De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Welzijn,

Rijksuniversiteit Te Utrecht

Hadassa Medical Organization

Tel Hashomer Medical Research Infrastructure and Services Ltd.

Irun R Cohen

Francisco Javier Quintana

Dana Elias

Ofer Lider

Raanan Margalit

Eytan Domany

Johannes Herkel

Felix Mor

Meir Shinitzky

Liora Cahalon

Pnina Carmi

Oded Shoseyov

Varda Rotter

Willem Van Eden

Gad Getz

Rachel Sorek

Doron Markovits

Guy Hed

Pennina Safer

Michal Eisenbach-Schwartz

Matityahu Fridkin

Rami Hershkoviz

Johannes D Van Embden

Ruurd Van Der Zee

Meirav Pevsner-Fischer

Noam Shental

Michael Sela

Yaakov Naparstek

Jonathan Kipnis

Alon Monsonego

Amiram Eldor

Eran Ovadia

Israel Vlodavsky

Neta Erez-Alon

Keren Jakobi-Brook

Rivka Abulafia

Jana Bockova

Ansgar W Lohse

Stephanie Konen-Waisman

Gideon B Moshe

Keren Jakobi

Andre Lwoff

Avishai Mimran

Na'aman Kam

Ittai Fattal

Neta Erez

Anat Reiner-Benaim

Eti Yoles

Roland Wolkowicz

Pedro Ruiz

Howard L Weiner

Jeffrey Sterling

Richard L Edelson

John Lawson Stanford

Yaacov Herzig

Graham A Rook

Lea Eisenbach

Yechiel Shai

Angel Porgador

Gabriel Nussbaum

Shimon Slavin

Tivadar Tamas

Alexandra Zanin-Zhorov

Gyorgy Toth

Zvi Ram

Istvan Miskolczi

Ferenc Rantal

Ilan Volovitz

Ehud Hauben

Aharon Yerushalmi

Pierre Beserman

Jelle E Thole

Ohad Birk

Jack Pennell

David Margel

Aaron Yerushalmi

Ayala Frenkel

Jack Baniel

Joseph Holoshitz

Ofer Yossepowitch

Guy Tal

Meirav Pevsner

Bracha Rager-Zisman

Hila Amir-Kroll

Noam Cohen

Rivka Abulafia-Lapid

Henri Atlan

Eli Sahar

Tomer Cohen

Gila Moalem

Meirav Pevsner-fischer

Francisco J Quintana

Assays and methods for diagnosing and treating autoimmune diseases. Particularly, the invention provides methods for differential diagnosis of specific autoimmune diseases, including autoimmune rheumatic disorders.

Diagnosis of autoimmune disease

Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.

Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens

The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.

Use of AKT phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same

Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

Diagnosis of systemic lupus erythematosus using oligonucleotides antigens

Diagnosis of autoimmune diseases

Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, provided is a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.

Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.

Identifying antigen clusters for monitoring a global state of an immune system

The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogs and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers.

A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 90 (HSP 90), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences. The disease is other than insulin dependent diabetes mellitus (IDDM) or rheumatoid arthritis. The administering of the immunogenic composition results in a shift of the immune response to a Th2 response, thereby treating the disease.

DNA vaccines encoding heat shock proteins

Compositions and methods comprising ampicillin or salts and derivative thereof for the treatment of delaying the onset of type I diabetes are provided.

Beta-lactam compounds for treating diabetes

Compositions and methods are provided, comprising at least one beta-lactam compound selected from the group consisting of cefuroxime, a penicillin, ceftriaxone, clavulanic acid, 6-aminopenicillanic acid (6-APA) and tazobactam, for enhancing T cell mediated immune responses in a subject, such as anti-tumor and anti-viral immune responses.

Beta-lactam compounds for enhancing T cell-mediated immune responses

Compositions and methods for prevention and treatment of Alzheimer's disease utilize a combination of amyloid-beta protein or a fragment thereof and a heat shock protein or a fragment thereof.

Vaccine for alzheimer's disease

Growing community of inventors

Rehovot, Israel

Irun R Cohen