Hoechst Aktiengesellschaft

Irmgard Hoffmann

Gerhard Rackur

Karl Schmitt

Ulrich Schacht

Werner Fulberth

Willi Stammberger

8-Aryl-5,6,7,8-tetrahydropyrazolo(3,4-b)(1,4)diazepine-1H,4H-5,7-diones of the formula ##STR1## in which R.sub.1 through R.sub.5 are as defined in the specification, and medicaments containing these having an anxiolytic action.

8-Aryl-5,6,7,8-tetrahydropyrazolo(3,4-B)(1,4)-diazepine-1H,

Compound of the general formula ##STR1## in which R.sub.1 and R.sub.2 are identical or different and represent hydrogen atoms or alkyl groups with 1-6 C atoms, it also being possible for one of the radicals R.sub.1 and R.sub.2 to be, in each case, a benzyl, trifluoromethyl or phenyl group, R.sub.3 denotes a hydrogen atom, an alkyl group which has 1-6 C atoms and is optionally substituted by an aryl group, an alkoxy group with 1-6 C atoms, a trifluoromethyl group, a dialkylamino group with 2-12 C atoms or a cycloalkyl group with 3-6 C atoms, an alkenyl or alkynyl group with 2-6 C atoms, a cycloalkyl group with 3-6 C atoms or a carbalkoxy group with 2-6 C atoms, R.sub.4 is a hydrogen atom and R.sub.5 can be a phenyl group, a phenyl group which is monosubstituted or disubstituted by methyl Cl, Br, F, nitro, cyano and or trifluoromethyl or a pyridyl group and medicaments containing same.

4-Aryl-5,6,7,8-tetrahydropyrazolo(3,4-B)-(1,5)diazepine-1H,4H-5,7-diones

What is disclosed are medicinal compositions, useful as anti-depressive agents, containing a compound of the formula; ##STR1## in which R.sub.1, R.sub.3 and R.sub.4, which may be identical or different, and represent hydrogen atoms or lower alkyl or aralkyl groups, and R.sub.2 and R.sub.2 ', which may be identical or different, represent hydrogen or halogen atoms, hydroxy or trifluoromethyl groups or lower alkyl, alkoxy or aralkoxy groups, it also being possible that two adjacent radicals form an alkylene-dioxy radical, and R.sub.5 represents a hydrogen or halogen atom, a hydroxy, trifluoromethyl or nitro group or a lower alkyl, alkoxy or aralkoxy radical, and their salts with acids (active substance A) together with 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4 (3H,5H)-dione (active substance B), and their use as antidepressive agent.

Medicinal composition and its use as antidepressive agent

4-Phenyl-8-amino-tetrahydroisoquinolines of the formula ##STR1## in which R.sub.1 stands for bromine and R.sub.2 stands for hydrogen or both R.sub.1 and R.sub.2 represent chlorine, and their salts with physiologically tolerated acids, pharmaceutical preparations prepared therefrom, process for the manufacture of these preparations and their use for the treatment of depressive conditions.

Growing community of inventors

Bad Soden am Taunus, Germany

Irmgard Hoffmann