Digma Medical Ltd.

Nitinotes Ltd.

Metacure Limited

Irit Yaniv

Tamir Wolf

Avia Herschkovitz

Dvir Keren

Yekaterina Dlugach

Ilan Ben-Oren

Shlomo Ben-Haim

Benny Rousso

Walid Haddad

Harold Lebovitz

Ilan Ben Oren

Paul Goode

Slava Starobinsky

Paul V Goode, Jr

Ricardo Aviv

The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

Methods and systems for blocking neural activity in an organ of a subject, preferably in the small intestine or the duodenum

Devices and methods of endolumenal formation of gastric sleeves are described. Some embodiments allow templating of a gastric sleeve by a gastric bougie, exposing a selected amount of tissue for suturing access, while maintaining sufficient internal working space for suturing within the template lumen.

Endoluminal sleeve gastroplasty

The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

Methods and systems for reducing neural activity in an organ of a subject

There is provided in accordance with an exemplary embodiment of the invention a method of treating diabetic patients comprising measuring a triglyceride level in a diabetic patient and applying a diabetes treatment according to the triglyceride level. Optionally, there is provided a method of screening. Alternatively or additionally, there is provided a method of weight loss. Alternatively or additionally, there is provided a method of relatively reducing HOMA-IR levels. Alternatively or additionally, there is provided a method of relatively reducing blood pressure. An exemplary device to apply the treatment is described.

Method of treating a patient

Apparatus () for treating a human patient, which includes one or more electrode contact surfaces (), which are configured to be applied to a fundus () of the patient. A control unit () is configured to drive the one or more electrode contact surfaces () to apply an electrical signal to the fundus () that chronically improves a blood glucose level of the patient, in order to treat the patient, without calculating an impedance of tissue of the fundus () based on a sensed parameter that varies in response to the electrical signal, for detecting eating by the patient or a characteristic of food eaten by the patient. Other embodiments are also described.

Gastrointestinal electrical therapy

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Ramat Gan, Israel

Irit Yaniv