Insight Biopharmaceuticals Ltd.

Other

Hadasit Medical Research Services and Development Ltd.

Insight Strategy Marketing Ltd.

Kahr Medical Ltd.

Insight Biopharmacenticals Ltd.

Iris Pecker

Israel Vlodavsky

Maty Ayal-Hershkovitz

Tuvia Peretz

Yael Friedmann

Elena Feinstein

Yael Friedman

Tuvia Perets

Daphna Miron

Oron Yacoby-Zeevi

Yinon Shlomi

Hanna Ben-Artzi

Yoav Peleg

Israel Michal

Ayelet Gilboa

Haim Moskowitz

Itai Bloch

Hanan Itzhaki

Eyal Zcharia

Madlene Mimon

Madelene Mimon

Yinon Schlomi

Orit Goldshmidt

PD1-4-1BBL variant fusion proteins are provided. Also provided are isolated polypeptides comprising a PD1 variant or a 4-1BBL variant. Also provided are polynucleotides and nucleic acid constructs encoding the PD1-4-1BBL fusion protein or the isolated polypeptide, host-cells expressing the same and methods of use thereof.

PD1-4-1BBL variant fusion protein and methods of use thereof

SIRPalpha-4-1BBL variant fusion proteins are provided. Also provided are isolated polypeptides comprising a SIRPalpha variant. Also provided are polynucleotides and nucleic acid constructs encoding the SIRPalpha-41BBL fusion protein or the isolated polypeptide, host-cells expressing same and methods of use thereof.

SIRPalpha-4-1BBL variant fusion protein and methods of use thereof

According to the present invention there is provided an antibody that specifically binds an epitope of a heparanase protein, the heparanase protein including an amino acid sequence as set forth in SEQ ID NO:2, provided that phenylalanine replaces tyrosine at position 246. The present invention also provides an antibody elicited by an epitope of a heparanase protein, the heparanase protein including an amino acid sequence as set forth in SEQ ID NO:2, provided that phenylalanine replaces tyrosine at position 246.

Heparanase specific molecular probes and their use in research and medical applications

The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin coding region fused to a unique 5'-UTR sequence and a truncated 3&#x2032;-UTR. The present invention also provides methods of synthesizing large amounts of erythropoietin and in increasing serum erythropoietin level in individuals in need thereof.

High level expression of recombinant human erythropoietin having a modified 5'-UTR

Heparanase specific molecular probes which can be used for detection of the presence, absence or level of heparanase expression and methods of utilizing same are provided.

A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.

Polypeptide having heparanase activity

A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.

The present invention relates to novel polynucleotides encoding polypeptides homologous to heparanase, nucleic acid constructs including these novel polynucleotides, genetically modified cells expressing the same, recombinant proteins encoded thereby and which may have heparanase or other glycosyl hydrolase activity, antibodies recognizing the recombinant proteins, oligonucleotides, analogs thereof and ribozymes derived from these polynucleotides.

Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase

A variety of heparanase specific antibodies which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific antibodies for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific antibodies for therapy of a condition associated with expression of heparanase; the use of a heparanase specific antibodies for quantification of heparanase in a body fluid; the use of a heparanase specific antibodies for targeted drug delivery; and the use of a heparanase specific antibodies as a therapeutic agent.

Heparanase specific antibodies and their use in research and medical applications

Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells

A method of treating a condition associated with heparanase expression by administering a heparanase activity neutralizing monoclonal anti-heparanase antibody, the monoclonal anti-heparanase antibody being for neutralizing heparanase catalytic activity.

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Rishon Lezion, Israel

Iris Pecker