Hovione Scientia Limited

Hovione International Limited

Hovione Holding Limited

Iris Duarte

Marcio Temtem

Tiago Fonseca

João Vicente

Márcio Temtem

Joao Vicente

Maria Jose Pereira

Luis Padrela

Ruben Pereira

Maria José Pereira

Filipe Gasper

The present invention discloses a method to continuously manufacture micro- and/or nanoparticles of single component particles or multi-component particles such as particulate amorphous solid dispersions or particulate co-crystals. The continuous method comprises the steps of 1. preparing a first solution comprising at least one component and at least one solvent and a second solution comprising at least one anti-solvent of the at least one component comprised in the first solution, 2. mixing said first solution and said second solution by means of microfluidization to produce a suspension by precipitation or co-precipitation, 3. feeding said suspension to a filtration system to obtain a concentrate stream, 4. feeding said concentrate stream to a spray dryer, 5. atomizing said concentrate stream using at least one atomization nozzle, 6. drying said atomized concentrate stream to obtain particles, and 7. collecting said particles. Single component particles or multi-component particles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compositions are also disclosed.

Continuous production of particles

Growing community of inventors

Lisbon, Portugal

Iris Duarte