Ajinomoto Co., Ltd.

Irina Vladimirovna Biryukova

Sergei Vladimirovich Mashko

Aleksandra Yurievna Skorokhodova

Vera Georgievna Doroshenko

Alla Valentinovna Belareva

Vitaliy Arkadyevich Livshits

Maria Viacheslavovna Vitushkina

Zhanna Iosifovna Katashkina

Natalia Viktorovna Stoynova

Joanna Yosifovna Katashkina

Andrey Yurievich Gulevich

Vladimir Yurievich Ermishev

Aleksandr Aleksandrovich Krylov

Danila Vadimovich Zimenkov

Viktor Vasilievich Samsonov

Sergey Vladimirovich Mashko

Olga Nikolaevna Igonina

Evgeniya Aleksandrovna Malykh

Irina Segreevna Shmagina

Irena Alexandrovna Kononova

Ivan Alexandrovich Butov

Natalya Sergeevna Plekhanova

Tatyana Aleksandrovna Gaydenko

Natalya Igorevna Minaeva

Aleksandr Dmitrievich Kivero

A method is described for producing an L-amino acid including the steps of cultivating in a culture medium an L-amino acid-producing bacterium belonging to the family Enterobacteriaceae to produce and accumulate the L-amino acid in the culture medium, cells of the bacterium, or both, and collecting the L-amino acid from the culture medium, the cells, or both, wherein said bacterium has been modified to overexpress a gene encoding a periplasmic adaptor protein.

Method of producing L-amino acids

The present invention provides a method for constructing recombinant translationally coupled operons, a method for producing useful metabolites using the bacterium containing the coupled operons, and a method for monitoring gene expression.

Method for constructing an operon containing translationally coupled genes

A method for producing lower alkyl ester of &#x3b1;-L-aspartyl-L-phenylalanine by cultivating a recombinantbacterium that has the ability to produce and accumulate an aromatic L-amino acid according in a culture medium to produce and accumulate L-phenylalanine in the medium and synthesizing lower alkyl ester of &#x3b1;-L-aspartyl-L-phenylalanine from the aspartic acid or its derivative and the obtained L-phenylalanine.

Method for producing a lower alkyl ester of &#x3b1;-L-aspartyl-L-phenylalanine

The present invention provides a method for producing an aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genusor, which has been modified to attenuate expression of the ydiN gene, the ydiB gene, or both.

Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family with attenuated expression of the ydiN gene or the ydiB gene or combination thereof

The present invention relates to a method for producing L-amino acid, such as L-phenylalanine and L-tryptophan, is provided using bacterium belonging to the genuswherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of protein encoded by the yddG gene from, wherein said protein has an activity to make said bacterium resistant to L-phenylalanine, a phenylalanine analogue, or a tryptophan analogue. The present invention further relates to a method for producing lower alkyl ester of &#x3b1;-L-aspartyl-L-phenylalanine.

[object Object]

Growing community of inventors

Moscow, Russia

Irina Vladimirovna Biryukova