Latvian Institute of Organic Synthesis

Other

Kalvins, Prof. Dr., Ivars

Irina Shestakova

Ivars Kalvins

Ilona Domracheva

Pavels Arsenjans

Jelena Vasiljeva

Gunars Duburs

Aivars Krauze

Signe Grinberga

Laura Krasnova

Elina Jaschenko

Ilze Adlere

Zigmars Andzans

Viktor Adrianov

Iveta Kanepe

Iveta Kanepe-Lapsa

Anita Gulbe

Valerjans Kauss

The present invention relates to a novel cancer metastasis preventing and curing selenopheno[h]chromene derivatives, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment and/or prevention of primary cancer and its metastasis by administration of such substances. 

Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents

The thieno[2,3-b]pyridines of general formula (I), whereinRis Me, CH, 3,4,5-(OMe)CH, NH;Ris H, CN, COMe, COOCalkyl, COOCHOMe, COOCHOPr(n);Ris CHR, 3,4-OCHO&#x2014;CH; 2-furanyl;

Thieno [2,3-b] pyridines as multidrug resistance modulators

Described are new 1-aziridino-1-hydroxyiminomethyl derivatives with the general formula (I), wherein R is able to is a single bond or a linker moiety capable of covalently bonding two aziridine oxime groups, Rand Rindependently of one another are selected from the group consisting of &#x2014;H, &#x2014;CH, &#x2014;CH, &#x2014;CN, &#x2014;COOH, &#x2014;COOCH, &#x2014;COOCH, &#x2014;CONH, or &#x2014;CHgroup, and n is the whole number 2, provided that Rand Rare not both &#x2014;H and provided that Ris not &#x2014;H if Ris &#x2014;CHand Ris not &#x2014;CHif Ris &#x2014;H The compounds of general formula (I) show antitumor activity.

1-aziridino-1-hydroxyiminomethyl-derivates, method for the production thereof and medicaments containing said compounds

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Riga, Latvia

Irina Shestakova