Sandoz Ag

Irina Kosilek

Franz Xaver Schwarz

Joan Cabre

Indranil Nandi

Mintong Guo

Chad Michael Gassert

Pere Lloveras

Norbert Atzl

An oral suspension comprising (a) an antibiotic composition which comprises coated micropellets and optionally one or more excipients, (b) additional excipients, and (c) a solvent, wherein said coated micropellets comprise (i) a core comprising at least one antibiotic; (ii) an inner coating comprising at least one cellulose polymer which is not an enteric coating polymer; and (iii) an outer coating comprising at least one enteric coating polymer, wherein said coated micropellets have a mean particle size of about 100 &#x3bc;m to about 650 &#x3bc;m. The oral suspension of the invention is characterized by a lack of bitter taste.

Antibiotic clarithromycin micropellet compositions

The present invention relates to a pharmaceutical composition for oral administration suitable for the preparation of a ready-to-use suspension comprising coated particles comprising an active substance having an unpleasant and/or bitter taste, such as clarithromycin, and a suspension base comprising an osmotically active substance capable of providing a high osmolality to the admixture of the suspension base with an aqueous suspending medium in the ready-to-use suspension. Said ready-to-use suspension maintains its palatability over a prolonged period of time by those defined osmotic conditions.

Taste-masking pharmaceutical compositions

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Kufstein, Austria

Irina Kosilek